基质交感分子1和骨保护素对急性冠脉综合征合并2型糖尿病患者经皮冠状动脉介入治疗术后支架内再狭窄的影响研究

Influence of STIM1 and OPG on In- stent Restenosis in Patients With ACS Complicated With T2DM After PCI

目的探讨基质交感分子1(STIM1)和骨保护素(OPG)对急性冠脉综合征(ACS)合并2型糖尿病(T2DM)患者经皮冠状动脉介入治疗(PCI)术后支架内再狭窄(ISR)的影响。方法选取2012年10月—2013年10月河北医科大学第三医院心内科收治的100例ACS合并T2DM患者为研究对象,均成功行PCI术。于术后8个月复查冠状动脉造影,根据是否存在ISR,分为ISR组35例和对照组65例。记录100例患者的性别、年龄、高血压、吸烟等一般资料;在PCI术前,测定患者的高敏C反应蛋白(hs-CRP)、血脂、血糖等生化指标;在PCI术后,测定患者的STIM1和OPG水平。结果两组的年龄、性别、吸烟率、高血压患病率比较,差异均无统计学意义(P>0.05)。两组患者的总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)水平比较,差异均无统计学意义(P>0.05);hs-CRP、STIM1、OPG水平比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,hs-CRP、STIM1、OPG对PCI术后发生ISR的影响有统计学意义(P<0.05)。结论 STIM1、OPG是ACS合并T2DM患者PCI术后发生ISR的危险因素。

Objective To investigate the influence of stromal interaction molecule 1 （ STIM1 ） and osteoprotegerin （ OPG） on in-stent restenosis （ ISR） in patients with acute coronary syndrome （ ACS） complicated with type 2 diabetes mellitus （T2DM） after percutaneous coronary intervention （ PCI） .Methods We enrolled 100 patients with ACS complicated with T2DM who were admitted into the Department of Cardiology of the Third Hospital of Hebei Medical University from October 2012 to October 2013.PCI was undertaken successfully on all the subjects .Eight months after surgery , coronary arteriography was conducted again.According to whether ISR occurred , we divided the subjects into two groups： ISR group （ n=35） and control group （n=65） .General data of the 100 subjects were recorded, including gender, age, hypertension and smoking; before PCI, we tested hs-CRP, blood lipid and blood glucose; after PCI, we determined STIM1 and OPG levels.Results The two groups were not significantly different （P〉0.05） in age, gender, smoking rate, prevalence of hypertension.The two groups were not significantly different （ P 〉0.05 ） in TC, TG, HDL-C, LDL-C and FPG; the two groups were significantly different （P〈0.05） in the levels of hs-CRP, STIM1 and OPG.Multivariate logistic regression analysis showed that hs-CRP, STIM1 and OPG had significant influence on ISR in subjects after PCI （ P〈0.05 ） .Gonclusion STIM1 and OPG are risk factors for patients with ACS complicated with T 2DM after PCI.