摘要
目的系统评价2型糖尿病患者并发肾脏疾病的影响因素。方法计算机检索美国国立医学图书馆(MEDLINE,1960.01—2012.12)、EMBase(1980.01—2012.12)、中国生物医学文献服务系统(CBM,1969.01—2012.12)、中国期刊全文数据库(CNKI,1981.01—2012.12)、中国科技期刊数据库(VIP,1989.01—2012.12)及万方数据资源系统(1998.01—2012.12)的相关文献。采用Rev Man 5.2统计软件对纳入文献进行Meta分析,探讨2型糖尿病患者并发肾脏疾病的影响因素。结果共纳入文献7篇,其中6篇为横断面研究,1篇为病例对照研究,总样本量为3 548例。Meta分析结果 :(1)病例对照研究的单因素分析显示,年龄对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并MD值为2.37〔95%CI(0.20,4.54)〕;横断面研究的单因素分析显示,年龄对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并MD值为5.61〔95%CI(1.54,9.68)〕。横断面研究的多因素分析显示,年龄对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并OR值为1.02〔95%CI(1.01,1.03)〕。(2)横断面研究的单因素分析显示,性别对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并OR值为1.28〔95%CI(1.03,1.58)〕。横断面研究的多因素分析显示,性别对糖尿病患者并发肾脏疾病的影响有统计学意义,合并OR值为0.46〔95%CI(0.22,0.95)〕。(3)病例对照研究的单因素分析显示,文化程度、婚姻状况及家庭经济收入对2型糖尿病患者并发肾脏疾病的影响无统计学意义,合并OR值分别为0.54〔95%CI(0.24,1.24)〕、1.77〔95%CI(0.92,3.41)〕及0.74〔95%CI(0.44,1.24)〕。(4)病例对照研究的单因素分析显示,自我效能分级(高等水平/低等水平)和症状管理自我效能分级(高等水平/低等水平)对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并OR值分别为0.24〔95%CI(0.10,0.60)〕和0.29〔95%CI(0.10,0.83)〕;多因素分析显示,自我效能(高等水平/低等水平)和自我效能(中等水平/低等水平)对2型糖尿病患者并发肾脏疾病的影响有统计学意义,合并OR值分别为0.30〔95%CI(0.11,0.87)〕和0.18〔95%CI(0.06,0.52)〕。结论社会人口学因素中的年龄、性别及心理因素中的自我效能,是2型糖尿病患者并发肾脏疾病的影响因素。
Objective To systematically review the influencing factors for type 2 diabetic kidney disease （ DKD） . Methods We made computer -based retrieval from MEDLINE （1960.01—2012.12）, EMBase （1980.01—2012.12）, CBM （ 1969.01—2012.12 ） , CNKI （ 1981.01—2012.12 ） , VIP （ 1989.01—2012.12 ） and Wanfang database （ 1998.01—2012.12） .RevMan 5.2 statistic software was used to conduct meta -analysis and investigate the influencing factors for type 2 diabetic kidney disease.Results We included 7 pieces of literature , among which 6 pieces were of cross -sectional study and one case was of case -control study.There were all together 3 548 subjects involved in the study .The results showed by the meta-analysis were as follows.（1） The univariate analyses of case -control study showed that age had influence on the occurrence of type 2 diabetic kidney disease , with a combining MD value of 2.37 〔95%CI （0.20, 4.54）〕; the univariate analyses of cross-sectional study showed that age had influence on the occurrence of type 2 diabetic kidney disease , with a combining MD＆amp;nbsp;value of 5.61 〔95%CI （1.54, 9.68）〕 .The multivariate analyses of cross -sectional research showed that age had influence on the occurrence of type 2 diabetic kidney disease , with a combining MD value of 1.02 〔95%CI （1.01, 1.03）〕 .（2） The univariate analyses of cross -sectional study showed that gender had influence on type 2 diabetic kidney disease , with a combining OR value of 1.28 〔95%CI （ 1.03, 1.58 ）〕 .The multivariate analyses of cross -sectional research showed that gender had influence on type 2 diabetic kidney disease , with a combining OR value of 0.46 〔95%CI （0.22, 0.95）〕 .（3） The univariate analyses of case -control study showed that education level , marital status and the total income of a household had no influence on type 2 diabetic kidney disease , with combining OR values of 0.54 〔95%CI （0.24, 1.24）〕, 1.77 〔95%CI （0.92, 3.41）〕 and 0.74 〔95%CI （0.44, 1.24）〕 respectively.（4） The univariate analyses of case -control study showed that self-efficacy （ high level/low level ） and self -efficacy of symptom management （ high level/low level ） had influence on type 2 diabetic kidney disease , with combining OR values of 0.24 〔95%CI （ 0.10, 0.60 ）〕 and 0.29 〔95%CI （ 0.10, 0.83）〕; multivariate analyses showed that self -efficacy （ high level/low level ） and self -efficacy （ intermediate level/low level） had influence on type 2 diabetic kidney disease , with combining OR values of 0.30 〔95%CI （0.11, 0.87）〕 and 0.18〔95%CI （0.06, 0.52）〕 respectively.Gonclusion Age, gender and self -efficacy are influencing factors for the occurrence of type 2 diabetic kidney disease .
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第22期2732-2736,共5页
Chinese General Practice
