柴胡疏肝散加减对类风湿关节炎伴随抑郁症治疗的临床观察

Clinical observation on the treatment of depressive symptoms and rheumatoid arthritis with Chaihu Shugan Powder

目的:观察中药柴胡疏肝散加减对伴有抑郁症的类风湿关节炎患者抑郁状态改善和生命质量提高的作用。方法:对68例患者抑郁症治疗前后的评定,随机分成对照组、观察组两组,对照组在抗风湿基础治疗上联合氟罗西汀,观察组在抗风湿基础治疗上联合中药柴胡疏肝散加减,进行临床对照观察。疗程均为2月。采用生活质量表、汉密尔顿抑郁量表(HAMD)、焦虑自评量表(SAS)分别观察两组的临床疗效和症候的改善情况。结果:经2个月治疗后两组患者的生活质量表、汉密尔顿抑郁量表(HAMD)、焦虑自评量表(SAS)都有改善(P<0.01),差异具有统计学意义。结论:中药治疗类风湿关节炎伴随抑郁症是有效且患者乐于接受的。

Objective ：To observe the clinical efficacy of Chaihu Shugan Powder on depressive symptoms and rheumatoid arthritis .Methods：68 patients with depressive symptoms were randomly divided into 2 groups：34 cases in control group treated with paroxetine ;34 cases in treatment group treated with oral Chaihu Shugan Powder（plus-minus）.Patients were regularly treated every day.After 2 months, HAMD.SAS mark were exam to evaluated the clinical efficacy and improvement of symptoms.Results： After treatment.scores of HAMD.SAS mark decreased （P〈0.01）and the changes were more significant in treatment group.Conclusion： Chaihu Shugan Powder can improve the clinical symptoms of depressive symptoms and rheumatoid arthritis has more advantages.