精神分裂症患者生活质量与药物治疗态度的相关性

Correlation between quality of life and medication attitude in patients with schizophrenia

目的探讨精神分裂症患者生活质量与药物治疗态度的相关性。方法连续入组151例在广州市脑科医院住院的符合《国际疾病分类(第10版)》(ICD-10)精神分裂症诊断标准的患者,分别采用健康状况量表(SF-36)、药物态度清单(DAI)、阳性和阴性症状量表(PANSS)评定其生活质量、药物治疗态度和临床症状。采用多重逐步回归分析生活质量的影响因素。结果治疗态度积极组57例,男性38例(66.7%),治疗态度消极组94例,男性40例(42.6%),积极组男性比例高于消极组;积极组SF-36心理健康维度(MCS)评分(46.8±9.1)分,消极组(41.0±10.8)分,两组比较差异有统计学意义(P<0.05);多重回归分析显示患者的药物治疗态度是生活质量的影响因素(B=2.025,β=0.309,P<0.05)。结论精神分裂症患者的药物治疗态度越积极,生活质量越好。

Objective To explore the correlation between quality of life and medication attitude among schizophrenic inpatients.Methods A total of 151 participants with schizophrenia were randomly recruited from Inpatient Department of Guangzhou Brain Hospital. The Short Form 36 Health Survey Questionnaire( SF- 36),the Drug Attitude Inventory( DAI) and the Positive and Negative Syndrome Scale( PANSS) were applied to assess quality of life,medication attitude and clinical symptoms respectively. According to DAI scores,participants were divided into positive medication attitude group and negative medication attitude group. Multiple stepwiseregression analysis was applied to analyze the influencing factors of quality of life. Results 57 patients were in the positive medication attitude group with 38 males( 66. 7%),while 94 in the negative group with 40 males( 42. 6%),as a result,the percentage of males was higher in the positive group,the scores of Mental Component Summary( MCS) were( 46. 8 ± 9. 1) and( 41. 0 ± 10. 8) of the positive and negative groups respectively,and the difference between the two groups was statistically significant( P < 0. 05). Multiple regression analysis showed that medication attitude is the influencing factor of quality of life in patients with schizophrenia( B = 2. 025,β= 0. 309,P < 0. 05). Conclusion Higher level of quality of life was correlated with better attitude toward medication.