伊曲茶碱合成工艺改进

Synthesis process optimization of istradefylline

以碳酸二甲酯、藜芦醛为起始原料,经过亚硝化、还原、上侧链、甲基化等反应工序,制备得到目标产物伊曲茶碱,工艺稳定、环境友好,且收率高、成本低具有广阔的市场前景。

Istradefylline was synthesized from ethamine and methyl- carbonate by condensation,cyclization,nitrosation and reduction,followed by cyclization and methylation. This technology had process stability,environment friendly,high yield,low cost,and broad market prospects.