HPV感染与宫颈鳞癌临床病理因素的相关性分析

Analysis of correlation between HPV infection and clinicopathological factors of cervical squamous cell carcinoma

目的:分析HPV感染与宫颈鳞癌临床病理因素的相关性。方法:回顾分析中南大学湘雅三医院因宫颈鳞癌行广泛子宫全切及盆腔淋巴结清扫的184例患者的HPV感染情况、TCT结果、肿瘤分期(IA^IIB)、分化程度、肿瘤直径、淋巴结转移情况、间质浸润深度等临床资料,探讨宫颈鳞癌患者HPV感染情况及其与临床病理因素的相关性。结果:184例宫颈鳞癌患者的HPV阳性率为92.9%,其中单一感染占63.6%,多重感染占29.3%,单一感染中前四位HPV感染类型依次为HPV16、18、58、45,多重感染中前四位HPV感染类型依次为HPV16、33、52、18。HPV单一感染的宫颈鳞癌患者较多重感染者的FIGO分期更晚且更易发展为巨块型宫颈癌;HPV感染类型与宫颈鳞癌的临床病理因素之间无相关性。结论:HPV感染模式可影响宫颈鳞癌的临床表现及复发相关因素。

Objective： To analyze the correlation between HPV infection and clinico- pathological factors of cervical squamous cell carcinoma. Methods： Clinical data of 184 cervical squamous cell carcinoma patients who had undergone radical hysterectomy and bilateral pelvic lymphadeneetomy were retrospectively analyzed, including HPV, TCT results, tumor staging （ IAIIB） , degree of differentiation, lymph node metastasis, tumor diameter, depth of stromal inva- sion. Results： HPV of any type was detected in 92.9% of all cases in which the single infection accounted for 63.6%, multiple infection accounted for 29.3% , among single infection the first four types were ： 16,18,58,45 ; among multiple 52,18. Statistic analysis indicates that： patients infection the first four types were：HPV16,33, with single hr-HPV infection in early cervical squamous cell carcinoma are more likely to develop bulky cervical cancer （tumor diameter 1〉 4cm）, and later FIGO stage;there is no correlation between HPV types and clinical pathological factors of squamous cell carcinoma of cervix. Conclusion：Pattern of HPV infection effects the clinical manifestations and recurrence factors of cervical squamous cell carcinoma.