秦皇岛地区青少年高非高密度脂蛋白胆固醇血症危险因素分析

The risk factors of high non-high density lipoprotein cholesterol in adolescents

目的探讨高非高密度脂蛋白胆固醇（non-HDL-C）血症在青少年中的检出率及相关危险因素,为探讨儿童高脂血症的有效控制方法提供基础数据。方法使用分层整群随机抽样方法,对秦皇岛地区3 136名13~17岁汉族青少年的non-HDL-C水平进行横断面调查。结果高non-HDL-C血症检出率为1.2%。三酰甘油和腰围正常组青少年高nonHDL-C血症检出率为0.5%,而HTWC组青少年检出率为9.8%。校正性别、年龄、糖尿病家族史和高血压家族史后,HTWC组青少年高non-HDL-C血症检出率是三酰甘油和腰围正常组青少年的19.696倍（95%CI=8.325~46.595,P〈0.01）。结论HTWC表型与青少年高non-HDL-C血症密切相关,为青少年高non-HDL-C血症的危险因素。

Objective The aim of the study was to explore the prevalence and risk factors of high non-high density lipopro- rein cholesterol （non-HDL-C） in adolescents. Methods A cross-sectional study was conducted on 3 136 Han adolescents aged 13 -17 years in Qinhuangdao. The high non-HDL-C was defined as non-HDL-C ≥3.76 mmol/L. The hypertriglyceridemic-waist （HT- WC） phenotype was defined as serum trlglyceride concentrations ≥ 1.47 mmol/L and waist circumference≥90 th percentile for age and sex. Results The prevalence of high non-HDL-C was 1.2%. The prevalence of high non-HDL-C was 0.5% in adolescents with normal waist circumference and triglyceride and 9.8% in adolescents with HTWC phenotype. After adjustment for sex, age, family history of diabetes and family history of hypertension, the prevalence of high non-HDL-C among adolescents with HTWC phenotype was 19.696 （95%CI= 8.325-46.595, P= 0.000） times than adolescents with normal waist circumference and triglycer- ide. Conclusion There is a significant correlation between HTWC phenotype and high non-HDL-C. This phenotype is an inde- pendent risk factor for high non-HDL-C.