氯氮平对女性精神分裂症患者主观睡眠的改善

The Improvement of Clozapine on Subjective Sleep in Female Patients with Schizophrenia

目的：探讨氯氮平对精神分裂症患者睡眠的影响。方法：选择符合DSM—IV诊断标准的女性精神分裂症患者65例，按治疗常规给予氯氮平单一用药治疗，用药前及用药4周后分别评定匹兹堡睡眠质量指标量表（PSQI）。应用SPSS17．0统计软件包进行统计分析。结果：患者服用氯氮平4周后主观感觉睡眠时间延长，睡眠质量提高。主观睡眠质量、入睡时间、睡眠时间、睡眠障碍、睡眠效率、催眠药物、日间功能、PSQI总分和服药前有明显差异，P值〈0．05。结论：精神分裂症患者存在有睡眠障碍，睡眠时间缩短，睡眠质量下降。氯氮平可以改善精神分裂症患者的睡眠，可以延长睡眠时间，提高睡眠质量。

Objective： To investigate the effects of clozapine on sleep in patients with schizophrenia. Methods： 65 cases of female schizophrenie patients met DSM - IV diagnostic criteria , routinely given clozapine monotherapy treatment , also give them the Pittsburgh Sleep Quality Index Assessment Scale （PSQI） before treatment and after 4 weeks. Application SPSS17.0 statistical software package for statistical analysis was used. Results： The subjective feeling sleep duration and sleep quality improved in patients taking clozapine after 4 weeks. There exist significant differences in Subjective sleep quality, time before sleep time, sleep disorder, sleep efficiency, sleep medication, daytime function, total score of pSQI and medication, P values 〈 0.05. Conclusion： There exist sleep disorders, sleep time, sleep quality in schizophrenia patients. Clozapine can improve sleep in patients with schizophrenia, it make sleep time longer and sleep quality higher.