超高效液相色谱-三重四极杆质谱联用同时检测环境水体中22种典型药品及个人护理用品

Simultaneous determination of 22 typical pharmaceuticals and personal care products in environmental water using ultra performance liquid chromatographytriple quadrupole mass spectrometry

应用超高效液相色谱-三重四极杆质谱联用仪（UPLC-MS/MS）建立了环境水体中22种典型药品及个人护理用品（pharmaceuticals and personal care products,PPCPs）的分析方法。通过对固相萃取柱、淋洗液、色谱流动相等的优化,确定以Oasis HLB小柱为固相萃取柱、甲醇为淋洗液、水（0.1%甲酸）-甲醇（7∶3,v/v）为流动相进行水样预处理和色谱分离。在最优条件下,目标物在水中的回收率为73%～125%,相对标准偏差（RSDs）为8.8%～17.5%。各目标物的线性范围均为2～2 000μg/L,线性相关系数（R2）不小于0.997。该方法具有检出限低、回收率高等优点,经实际样品测试,适用于环境水体中22种典型PPCPs的同时检测,可为微量有机物引起的水环境风险评价和控制的相关研究提供支持。

An analytical method for simultaneous determination of 22 typical pharmaceuticals and personal care products （PPCPs） in environmental water samples was developed by ultra performance liquid chromatography-triple quadrupole mass spectrometry （UPLC-MS/MS）. An Oasis HLB solid phase extraction cartridge, methanol as washing solution, water containing 0. 1% formic acid-methanol （7：3, v/v） as the mobile phases were selected for sample pretreat- ment and chromatographic separation. Based on the optimized sample pretreatment procedures and separation condition, the target recoveries ranged from 73% to 125% in water with the rela- tive standard deviations （RSDs） from 8.8% to 17.5%, and the linear ranges were from 2 to 2 000 μg/L with correlation coefficients （R2） not less than 0. 997. The method can be applied to simultaneous determination of the 22 typical PPCPs in environmental water samples because of its low detection limits and high recoveries. It can provide support and help for the related research on water environmental risk assessment and control of the micro-organic pollutants.