120株复发肺结核患者结核分枝杆菌耐药性分析

The Analysis of Drug Resistance of Mycobacterium tuberculosis in 120 Cases of Recurrent Tuberculosis Patients

目的本研究对复发肺结核患者结核分枝杆菌耐药性进行分析,为相关的临床治疗提供参考。方法本文对我院2010年2月至2014年2月期间诊治的120例复发性肺结核患者分离的菌株进行耐药性分析,并对前后两次发病菌株进行散在分布重复单位(MIRU)进行基因型分型。以120例同期初治肺结核患者为对照组,比较两组患者之间结核分枝杆菌的耐药性差别。结果女性患者分离菌对抗结核药物耐药率更高(P<0.05),但分离菌株的基因型无统计学差异性。复治组结核分枝杆菌的耐多药性和广泛耐药性比例明显高于对照组,且具有显著的统计学差异性(P<0.01)。结论复发肺结核患者女性比例较高,与菌株基因型无相关性,且菌株的多耐药性及广泛耐药性比例明显高于初治组患者。

Objective Aim The present research aimed to investigate the drug resistance of Mycobacterium tubercu-losis in patients with recurrent tuberculosis.Methods 120 cases of recurrent tuberculosis patients in our hospital from Feb 2010 to Feb 2014 were analyzed.The MIRU genotype of Mycobacterium tuberculosis in patients was detected.120 cases of initial treatment patients at the same time were taken as control.The drug resistance type was analyzed be-tween the two groups.Results Mycobacterium tuberculosis isolated in female patients showed higher drug resistance, but signified no statistical difference in genotype.Retreatment patients manifested higher multidrug resistance and ex-tensively drug-resistance and lower single resistance when compared with control with a significant statistical differ-ence.Conclusion Recurrent tuberculosis occurs higher in female patients and signifies multi-drug and extensively-drug resistance when compared with control.