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Cx43、PTEN在卵巢上皮性肿瘤组织中的表达及临床意义 被引量：4

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摘要 卵巢癌是女性生殖系统肿瘤中死亡率最高的肿瘤,由于卵巢组织的解剖与内分泌的复杂性使卵巢癌的早期诊断极为困难因此,寻找卵巢恶性肿瘤早期诊断指标已经成为研究热点。间隙连接蛋白43（connexin 43,Cx43）为一种细胞间隙连接蛋白,多种肿瘤细胞中都有间隙连接蛋白43表达的下降与缺失[1]。同源磷酸酶-张力蛋白（phosphatase and tensin homolog deleted on chromosome ten,
作者 张妍 张舵舵 杨泽成 王莹 冷维春
机构地区 吉林大学中日联谊医院 吉林大学第一医院 吉林大学第二医院 内蒙古包钢第三职工医院
出处 《中国实验诊断学》 2015年第8期1363-1365,共3页 Chinese Journal of Laboratory Diagnosis
关键词 卵巢上皮性肿瘤 CX43 卵巢恶性肿瘤 间隙连接蛋白 细胞生长 张力蛋白 deleted 上皮性卵巢癌 交界性肿瘤 chromosome
分类号 R737.31 [医药卫生—肿瘤]
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参考文献8

  • 1Solan JL, Lampe PD. Connexin43 phosphorylation: structural changes and biological effects[J]. Biochem J, 2009,419 ( 2), 261.
  • 2Song MS, Carracedo A, Salmena L, et al. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase in dependent manner[J]. Cell,2011, 144 : 187.
  • 3Simon KW, Roberts PC, Vespremi MJ. Regulation of beta-catenin and connexin-43 expression: targets for sphingolipids in colon cancer prevention[J]. Mol Nutr Food Res, 2009,53 (3) : 332.
  • 4Murray SA, Davis K, Fishman LM, et al. Alpha connexin43 gapiunction are decreased in human adrenocortical tumors[J]. J Clin EndocrinolMetab, 2000,85 (2) : 890.
  • 5McLachlan E,Shao Q,Laird DW. Connexins and gap junctions in mammary gland development and breast cancer progression[J]. Membr Biol,2007,218(1 3) :107.
  • 6胡叶青,刘元姣.Cx43、Skp2在卵巢上皮性肿瘤组织中的表达及临床意义[J].癌症,2005,24(1):104-109. 被引量：17
  • 7Roy S,Yu Y,Padhye S. SB,et al. Difluorinated-Curcu-mim(CDF) Restores PTEN Expression in Colon Cancer Cells by Down-Reg- ulating miR-21[J]. PLos ONE,2013,8(7) :e68 543.
  • 8Perry JM, He XC, Sugimura R, et al. Cooperation between both wnt/b-catenin and PTEN/PI3K/Akt signa-ling promotes p-re- newal and expansion [J]. Genes DeV,2011,25 : 1928.

二级参考文献33

  • 1Dong Y, Sui L, Watanabe Y, et al. S-phase kinase-associaed protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications[J]. Oncol Rep, 2003, 10(2): 321-325.
  • 2Dowen SE, Scott A, Mukherjee G, et al. Overexpression of Skp2 in carcinoma of the cervix does not correlate inversely with p27 expression [J]. Int J Cancer, 2003, 105(3):326-330.
  • 3Shigemasa K, Ga L, O' Brien TJ. Skp2 overexpression is a prognostic factor in patients with ovarian adenocacinoma [J].Clin Cancer Res, 2003, 9(5): 1756-1763.
  • 4Chen SC, Pelletier DB, Ao P, et al. Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases [J]. Cell Growth Differ,1995, 6(6): 681-690.
  • 5Zhang YW, Morita I, lkeda M, et al. Connexin43 suppresses proliferation of osteosarcoma U2OS cells through posttranscriptional regulation of p27 [J]. Oncogene, 2001, 20(31): 4138-4149.
  • 6Zhang YW, Nakayama K, Morita 1, et al. A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2) [J]. Cancer Res, 2003, 63(7): 1623-1630.
  • 7Zhang YW, Kaneda M, Morita I. The gap junctionindependent tumor-suppressing effect of connexin43 [J]. J Biol Chem, 2003, 278(45):44852-44856.
  • 8King TJ, Fukushima LH, Hieber AD, et al. Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression [J]. Carcinogenesis, 2000, 21(6) : 1097-1109.
  • 9Hanna EA, Umhauer S, Roshong SL, et al. Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro [J]. Carcinogenesis, 1999, 20(7):1369-1373.
  • 10Umhauer S, Ruch R J, Fanning J. Gap junctional intercellular communication and connexin43 expression in ovarian carcinoma[J]. Am J Obstet Gynecol, 2000, 182(5): 999-1000.

共引文献16

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二级引证文献15

中国实验诊断学
2015年 第8期

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