樟脑基苯基硫脲类化合物的合成及生物活性研究

Syntheses and Biological Activities of Camphor-Based Phenyl Thiourea Compounds

以D-(+)-樟脑为原料,经肟化、还原得到樟脑胺,再与取代苯基异硫氰酸酯反应,合成得到10个未见文献报道的樟脑基苯基硫脲化合物(5a^5j),其结构通过FT IR、1H NMR、13C NMR和ESI-MS表征确认。初步生物活性测试表明,目标化合物在浓度50mg/L下对5种供试植物病原菌显示不同程度的抑菌活性,其中化合物5f(R=m-OCH3)和5d(R=p-CH3)对苹果轮纹病菌(Physalospora piricola)和番茄早疫病菌(Cercospora arachidicola)的抑制率分别达83.9%和82.2%;在浓度100mg/L下,化合物5i(R=p-Br)对油菜(Brassica campestris)胚根生长的抑制率为60.2%。

Ten novel camphor-based phenyl thiourea compounds （5a -5j） were synthesized by the reaction of camphoramine obtained from oximation and reduction of D-（ ＋ ）-camphor with various substituted phenyl isothiocyanates. Their structures were identified by FT IR, 1H NMR,13 C NMR and ESI-MS. The preliminary bioassay showed that, at the concentration of 50 mg/L, they exhibit different fungicidal activities against the five tested fungi, among them, compounds 5f （ R = m-OCH3 ） and 5d （ R = p-CH3 ） have inhibition rates of 83.9% and 82.2% against Physalospora piricola and Cercospora arachidicola, respectively. Besides, at the concentration of 100 nag/L, compound 5i （R =p-Br） displays growth inhibition rate of 60.2% against rape root （Brassica campestris）.