摘要
目的:确定长春西汀注射液的最优处方和最佳制备工艺。方法:选择不同的p H值、抗氧剂及不同的投料顺序,采用正交设计试验对处方及制备工艺进行筛选。结果:确定了最终的处方和制备工艺:抗氧剂维生素C与焦亚硫酸钠用量均为0.1%,溶液最佳p H值为3.5,采用分步投料工艺比较合理。结论:按优选的辅料用量及工艺制备的长春西汀注射液处方合理、工艺可行、质量稳定。
Objective： To optimize the formulation and preparation technology of Vinpocetine Injection. Methods： The orthogonal design was adopted to screen the formula technology. Different pH, antioxidants and different orders of adding raw materials are main factors. Results： Final formulation and preparation technology are as follows： the percentage of vitamin C and sodium metabisulfite are 0.1%. The optimum pH value is 3.5. Adding raw materials step by step is reasonable. Conclusion： The Vinpocetine Injection prescription prepared by the optimized preparation technology above is feasible and stable in quality.
出处
《中医药导报》
2015年第17期36-38,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
长春西汀注射液
正交试验
制备工艺
抗氧剂
Vinpocetine injection
orthogonal design
prescription process
antioxidant
