体外受精-胚胎移植对乙型肝炎病毒母婴传播影响的回顾性研究

A retrospective study on the vertical transmission of HBV infected pregnant women through fertilization-embryos transfer in vitro

目的探讨体外受精-胚胎移植技术(in vitro fertilization-embryos transfer,IVF-ET)是否会增加HBV DNA阴性HBV感染孕妇的母婴垂直传播率及对新生儿的影响。方法采用回顾性调查方法对42例HBV DNA阴性HBV感染者IVF-ET所分娩新生儿及45例HBV DNA阴性HBV感染者自然受孕所分娩新生儿进行对比分析,采用t检验和χ2检验进行统计学分析,观察两组新生儿出生时及生后7个月HBV感染率及HBV DNA定量比较,并对比观察新生儿出生体重、身长、窒息率等。结果 HBV DNA阴性HBV感染者IVF-ET组及自然受孕组所分娩新生儿HBV感染率无统计学差异(P=0.703),HBV DNA均为阴性,两组新生儿出生体重、身长、新生儿窒息率等均无统计学差异(P分别为0.167,0.463,0.297)。结论 IVF-ET不增加HBV DNA阴性HBV感染孕妇的母婴垂直传播率,对新生儿无不良结局。

ObjectiveTo explore the vertical transmission incidence of HBV infected pregnant women with HBV DNA negative and the influence of the infants by using IVF-ET.MethodsThe infants of 42 and 45 pregnant women wtih negative HBV DNA delivered by IVF-ET and without IVF-ET were compared and analyzed, respectively,ttest andχ2test were used for statistical analysis. The incidence of vertical transmission, the weight, body length and neonatal asphyxia on the infants between the two groups were observed.Results The incidence of vertical transmission, the weight, body length and the neonatal asphyxia between the two groups had no signiifcant difference （P = 0.703, 0.167, 0.463, 0.297）.ConclusionsIVF-ET dose not increase the incidence of the vertical transmission on pregnant women with HBV negative and there are no bad outcomes on the infants.