海洋蓝细菌抗肿瘤活性肽类的研究

Antineoplastic lipopeptides from marine cyanobacteria

海洋蓝细菌种类多分布广,其次生代谢产物具有特殊的化学结构和广泛的生物活性。脂肽类是一类结构新颖的化合物,具有抗菌、抗肿瘤、抗炎等生物活性,近年来受到人们的广泛关注。其中,抗肿瘤化合物的研究及开发显现出十分诱人的前景。以海洋蓝细菌为探讨对象,综述了海洋蓝细菌产生的抗肿瘤活性肽类成分的研究进展,最后对海洋蓝细菌的发展前景进行了展望。

Marine cyanobacteria are a rich source of complex bioactive secondary metabolites which derive from mixed biosynthetic pathways. lipopeptides were characteristic with novel structures and more attentions were paid in the recent years. Lipopeptides showed various bioactivities including antibacterial, anti-tumor, anti-inflammatory, etc. The research and development of antineoplas-tic compounds showed attractive foreground. This paper reviewed antineoplastic lipopeptides of marine cyanobacteria. In addition, the prospects of the development of marine cyanobacteria were also reviewed.