基于修订的心室肌细胞模型的短QT综合征病理仿真

Pathology Simulation of Short QT Syndrome Based on an Improved Model of Ventricular Myocytes

基于已公布的人体心室肌细胞模型数据建立了一维心室肌细胞模型,仿真了伪心电图及心内膜细胞、心中间膜细胞和心外膜细胞这三种细胞的动作电位.基于构建的模型进行周期实验,针对实验中出现的问题修订模型中的参数.将修订后模型的仿真结果与已经公布的实验数据进行对比,从而验证模型修订的合理性和可靠性.最后基于修订的心室肌细胞模型对与KCNJ2有关的短QT综合征的病理情况进行仿真,分析仿真结果,验证了修订模型的实用性.

Based on the data of the existing human ventricular cell model, a one-dimensional ventricular cell model is established. The pseudo ECG, action potentials for the endocardium cell, the mid-myocardium cell and the epicardium cell are simulated. The cycle simulation is carded out based on the established model, the parameters in the model are revised according to the problems encountered in the simulation process. It can be seen by comparing the existed experiment data with the simulation results that the improved model is reasonable and reliable. The KCNJ2- correlated short QT syndrome pathological conditions is also simulated by the improved model and the model proposed is validated.