维生素C联合环磷腺苷在小儿病毒性心肌炎中的应用

The application of Vitamin C combined with adenosine cyclophosphate in children with viral myocarditis

目的:探讨维生素C联合环磷腺苷在小儿病毒性心肌炎中的应用价值。方法:将病毒性心肌炎患儿130例随机分为对照组和观察组各65例;对照组患儿进行常规治疗,观察组在常规治疗的基础上,给予维生素C联合环磷腺苷治疗;观察2组相关指标变化。结果:治疗后观察组患儿的治疗有效率明显高于对照组(P<0.01)。观察组肿瘤坏死因子-α、白细胞介素-6和白细胞介素-8水平均明显低于对照组(P<0.01)。观察组超氧化物歧化酶与谷胱甘肽过氧化物酶水平均明显高于对照组(P<0.01),而丙二醛水平明显低于对照组(P<0.01)。观察组的肌酸激酶、肌酸激酶同工酶和心肌肌钙蛋白I水平均明显低于对照组(P<0.01)。结论:维生素C联合环磷腺苷治疗小儿病毒性心肌炎疗效确切,可有效减轻炎症反应,抗脂质过氧化,保护心肌细胞,值得临床推广。

Objective：To investigate the application value of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis. Methods：One hundred and thirty children with viral myocarditis were randomly divided into the control group and observation group（65 cases in each group）. The control group and observation group were treated with conventional therapy and vitamin C combined with adenosine cyclophosphate based on conventional therapy,respectively. The related index changes between two groups were compared. Results：The effective rate of treatment in observation group was significantly higher than that in control group（ P〈0. 01）. The levels of the tumor necrosis factor-a,interleukin-6 and the interleukin-8 in observation group were significantly lower than those in control group（P 〈0. 01）. The levels of the superoxide dismutase and glutathione peroxidase in observation group were significantly higher than those in control group（P〈0. 01）. The levels of the malondialdehyde,creatine kinase,creatine kinase-MB and cardiac troponin I in observation group were significantly lower than those in control group（P〈0. 01）. Conclusions：The curative effect of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis is exact, which can effectively reduce the inflammatory reaction,resist lipid peroxidation and protect cardiac muscle cell,and is worthy of clinical promotion.