心力衰竭患者内皮素1和脑钠肽的改变及相关性研究

The correlation research of serum endothelin-1 and brain natriuretic peptide levels in heart failure patients

目的:探讨心力衰竭患者内皮素1(ET-1)与脑钠肽(BNP)的改变及其相关性研究。方法:选择120例心力衰竭患者为观察组,同期健康体检者80名为对照组。比较2组血清ET-1及BNP,同时记录观察组不同心功能(纽约心脏病协会,NYHA)分级患者血清ET-1和BNP水平,探讨二者与心力衰竭严重程度的相关性。结果:观察组患者血清ET-1和BNP水平均显著高于对照组(P<0.01);随着心功能NYHA分级的增高,观察组患者左心室射血分数显著降低,左心室舒张末期内径、血清ET-1和BNP水平均显著升高(P<0.01);相关分析显示:BNP、ET-1水平均与NYHA分级呈显著正相关关系(P<0.01),ET-1与BNP水平亦呈明显正相关关系(P<0.01)。结论:心力衰竭患者血清BNP和ET-1显著升高,且与心力衰竭严重程度密切相关,二者可作为评估病情及预后的预测指标。

Objective：To observe the changes of serum endothelin-1 （ET-1） and brain natriuretic peptide（BNP） levels in heart failure patients and explore the correlations. Methods：One hundred and twenty cases with heart failure were selected as observation group and 80 healthy persons as control group. Serum ET-1 and BNP levels were compared between the two groups. ET-1 and BNP levels in different New York heart association（NYHA） gradation patients were also recorded and their correlation with the degree of heart failure was explored. Results：Serum ET-1 and BNP levels in observation group were much higher than those in control group （P 〈 0.01 ）. With the increase of NYHA gradation,left ventricular ejection fraction was obviously decreased,left ventricular end diastolic, ET-1 and BNP levels were significantly increased in observation group（ P 〈0.01 ）. Pearson correlation analysis showed that ET-1 and BNP levels had significant positive correlation with NYHA gradation（ P 〈 0.01 ）. There was the positive correlation between ET-1 and BNP levels （P 〈 0.01 ）. Conclusions： Serum ET-1 and BNP levels were greatly increased in heart failure patients, and closely related to disease severity. They can be the predictive indexes for evaluating disease condition and prognosis.