CXC16与急性冠脉综合征的相关性研究

To research association between CXCL16 and acute coronary syndrome

目的探讨急性冠脉综合征（ACS）患者血清CXCL16及MMP-2／9的表达水平，观察3者表达与动脉粥样硬化进展程度的关系以及CXCL16与MMP-2／9之间的相关性，并探讨炎症指标和斑块稳定性之间的关系，为临床有效地对冠心病进行诊断、治疗和预后的评估提供实验依据。方法用ELISA法检测ACS患者，包括不稳定型心绞痛（UAP）38例。急性心肌梗死（AMI）38例及对照组20例患者的血清CXCL16和MMP-2／9水平并作比较，同时分析血清CXCL16与血清MMP-2／9的相关关系。结果与对照组相比，UAP组和AMI组CXCL16均显著升高，差异有统计学意义（均P〈0．01）；与uAP组相比，AMI组CXCL16显著升高，且差异有统计学意义（P〈0．05）。与对照组相比，UAP组和AMI组MMP-2／9均显著升高，差异有统计学意义（均P〈0．01）；与UAP相比，AMI组MMP-2／9显著升高，且差异有统计学意义（P〈0．01）。血清CXCL16与MMP-2、MMP-9均存在显著线性相关关系（r=0．622，P〈0．01；r=0．572，P〈0．01）。结论血清CXCL16是ACS一个独立的生物学指标，并可以作为评价动脉粥样硬化斑块稳定性的指标。

Objective To investigate the changes of plasma CXCL16 and matrix metaUoproteinase - 2/9（MMP - 2/9） level in patients with acute coronary syndrome（ACS）. To investigate whether serum levels of CXCL16 are associated with serum levels of MMP- 2/9. Methods EIJSA was used to examine the level of serum - soluble CXCL16,MMP - 2/9 in 38 unstable angina peetoris patients（UAP）,38 acute myocardial infarction patients（AMI）and 20 control patients. Results In patients with UAP and AMI,semm level of CXCL16 was significantly increased compared to control patients（UAP patients vs control, P 〈 0.01. AMI patients vs control, P 〈 0.01 ）. In patients with AMI, serum level of CXCL16 was signifieandy increased compared to UAP patients（AMI patients vs UAPpatients, P 〈 0.05）. In patients with UAP and AMI,semm level of MMP - 2/9 was significantly in- creased compared to control patients（UAP patients vs control, P 〈 0.01. AMI patients vs control, P 〈 0.01 ）. In patients with AMI,semm level of MMP-2/9 was significandy increased compared to UAP patients（AMI patients vs UAPpatients, P 〈 0.01 ）. There is significant association between serum CXCL16 and MMP - 2,MMP - 9（ r = 0.622, P 〈 0.01 ; r = 0.572, P 〈 0.01 ）. Conclusion Increased level of serum - soluble CXCL16 was independently associated with ACS and it can be used as evaluation of atheroselemtie plaque stability indicators and have some have some correlations with aspirin.