中西医结合治疗神经根型颈椎病临床研究

The Clinical Research into Nerve Root Type Cervical Spondylosis Treated with Therapy of Integrated Traditional Chinese and Western Medicine

目的:观察中西医结合治疗神经根型颈椎病(CSR)的临床疗效。方法:选择神经根型颈椎病气血不足证患者124例,按数字表法随机分为治疗组和对照组各62例,对照组采用扶他林口服治疗,每次75 mg,日1次,同时配合牵引治疗,每次30 min,日1次。治疗组在对照组治疗的基础上采取气血双补荣筋汤治疗,日1剂,常规水煎分2次服用;同时将气血双补荣筋汤研磨进行离子导入治疗,每次25 min,日1次。两组疗程均为4周。比较两组患者临床评价量表(Clinical evaluation scale,CASCS)评分和中医临床症状积分;检测两组患者血IL-6和IL-10水平。结果:治疗组治疗后CASCS各指标评分和总积分均明显高于对照组(P<0.01);治疗组有效率为91.94%,对照组有效率为77.42%,治疗组疗效明显优于对照组(χ2=3.978,P<0.01);治疗组治疗后中医临床症状各指标评分均明显低于对照组(P<0.01);治疗组治疗后血清IL-6水平明显低于对照组,而IL-10水平显著高于对照组,差异均有统计学意义(P<0.01)。结论:中西医结合治疗CSR可明显提高CASCS评分,减轻临床症状,提高临床治疗疗效,降低患者血清IL-6水平和升高IL-10可能是其作用机制之一。

Objective： To observe the clinical curative effect of therapy of integrated traditional Chinese and Western medicine on nerve root type cervical spondylosis. Methods： One hundred and twenty-four patients with nerve root type cervical spendylosis due to syndrome of deficiency of qi and blood were divided into the treatment group and the control group according to random number method, with 62 cases in each group. The ones in the control group were given Votalin for oral administration （75 mg each time and once daily ） in combination with traction （30 minutes each time and once daily）, while the ones in the treatment group were added Decoction for Nourishing Both Qi and Blood and Tonifying Tendons （DNBQBTY）, 1 dose each day which was decocted in common water and taken for 2 times, based on the treatment of the control group. At the same time, Prescription of NBQBTr was Ground for ion-intreduction therapy, 25 minutes each time and once daily. Both groups regarded 4 weeks as a course. Then the clinical evaluation scale score and TCM clinical symptoms score of both groups were compared; And their IL-6 and IL-IO levels were detected. Results： After the treatment, each index score of CASCS and the total score of the treatment group were much higher than those of the control group （P 〈0.01 ）. The effective rate of the treatment group was 91.94%, which was much better than that （77.42%） of the control group（χ2 = 3. 978 ,P 〈 0.01 ）. After the treatment, each index score of TCM clinical symptoms of the treatment group was much lower than those of the control group （ P 〈0. 01 ）. After the freatmenl, the serum IL-6 level of the treatment group was much lower than that of the control group, but its IL-10 level was much higher that of the control group; All the differences between had statistical significance （P 〈 0. 01 ）. Conclusion： Therapy of integrated traditional Chinese and Western medicine can greatly improve CASCS score, relieve the clinical symptoms, enhance the clinical curative effect, reduce the IL-6 level and increase IL-10 level of patients with nerve root type cervical spondylosis, which may be one of its working mechanisms.