盐酸川芎嗪注射液联合足浴治疗糖尿病足50例

Fifty Cases of Diabetic Foot Treated with Ligustrazine Hydrochloride Injection in Combination with Foot Bath Treatment

目的：观察盐酸川芎嗪注射液联合足浴治疗糖尿病足的临床疗效。方法：将100例糖尿病足患者随机均分为对照组与观察组各50例,对照组给予糖尿病常规治疗,观察组在对照组治疗的基础上给予常规血糖控制与盐酸川芎嗪注射液联合中药浴足治疗。比较两组患者临床疗效,中医临床证候积分变化及治疗前后FBG,PBG,Hb Alc、TC及TG的变化情况。结果：对照组有效率为72.00%,显著小于观察组的96.00%（P〈0.05）;两组患者治疗前后中医证候积分差异均具有统计学意义（P〈0.05~0.01）,且观察组治疗后中医证候积分显著小于对照组治疗后（P〈0.05）;对照组治疗前后FBG,PBG,Hb Alc、TC及TG变化无统计学差异（P〉0.05）,但观察组治疗前后上述指标相比,差异均具有统计学意义（P〈0.05~0.01）,且观察组治疗后上述指标与对照组治疗后相比,差异均具有统计学意义（P〈0.05）;观察组治疗后生存质量显著优于对照组（P〈0.05）;两组治疗过程中均未见任何不良反应的发生。结论：盐酸川芎嗪注射液联合足浴治疗糖尿病足疗效显著。

Objective： To observe the clinical curative effect of lignstrazine hydroehloride injection in combination with foot bath treatment on diabetic foot. Methods ： One hundred patients with diabetic foot were randomly divided into the control group and the observation group, with 50 cases in each group. The ones in the control group were given diabetic routine treatment, while the ones in the observation group were added routine blood sugar control, ligustrazine hydrochloride injection in combination with TCM foot bath on the basic treatment of the control group. Then the clinical curative effects, TCM clinical syndrome score chan- ges, the changes of FB G,PB G, HbAIe, TC and TG before and after the treatment were compared. Results： The effective rate of the control group was 72.00%, which was obviously lower than thai of the observation group： 96.00% （ P 〈 0.05 ）. TCM clinical syndrome scores before and after the treatment in both groups all had statistical significance（ P 〈0.05 -0.01 ） ; And the ob- servation group was obviously smaller than the control group after the treatment. The changes of FB G, PB G, HbAIc, TC and TG before and after the treatment of the control group had no statistical difference （P 〉0.05）, but those indexes of the observation group all had statistical significance（ P 〈0.05 -0. 01 ）; And ＇after the treatment in terms of the above indexes, the differences between both groups had statistical significance（ P 〈 0. 05 ）. The survival quality of the observation group was much better than that of the control group（ P 〈 0.05 ）. During the treatment, there were no adverse reactions in both groups. Conclusion： Ligus- trazine hydroehloride injection in combination with foot bath treatment has remarkable clinical curative effect on diabetic foot.