可溶性纤溶酶原激活物受体在社区获得性肺炎中的表达及临床意义

Expression and Clinical Significance of su PAR in Patients with Community-Acquired Pneumonia

目的:探讨可溶性尿激酶型纤溶酶原激活物受体(su PAR)在成人社区获得性肺炎(CAP)住院患者中的表达及临床意义。方法:采用用酶联免疫吸附试验(ELISA)法测定61例住院CAP患者治疗前后及60例健康对照者的血浆su PAR水平,测定所有研究对象的CRP、WBC及PCT水平,CAP患者入院时进行肺炎CURB-65及APACHEⅡ评分,分析血浆su PAR与PCT、CRP、CURB-65、APACHEⅡ及住院时间的相关性。结果:肺炎治疗前su PAR、CRP、WBC及PCT水平均显著高于对照组,肺炎治疗后su PAR、CRP、WBC及PCT水平较治疗前显著降低,以上各项比较差异均有统计学意义(P<0.01);重症肺炎组住院时间、APACHEⅡ评分、CURB-65评分及血su PAR、CRP、WBC、PCT含量均显著高于非重症肺炎组,比较差异均有统计学意义(P<0.01);血浆su PAR水平与PCT、CRP水平,CURB-65、APACHEⅡ评分及住院时间有相关性。结论:su PAR对社区获得性肺炎有一定的诊断价值,su PAR水平对肺炎的病情程度有一定的评估作用,在指导治疗等方面具有一定的价值。

Objective： To investigate the expression and clinical significance of soluble urokinase-type plasminogen activator receptor（ suPAR ） in patients with CAP. Method： The plasma suPAR levels of 61 adult patients with CAP and 60 healthy patients were measured by the method of enzyme-linked immunosorbent assay （ ELISA ） .The levels of CRP, WBC and PCT of all research objects were measured.Tbe APACHE Ⅱ and CURB-65 scores were evaluated when the patients were hospitalized. The relationship between plasma suPAR and PCT, CRP, CURB-65 score, APACHE Ⅱ score, length of stay were analyzed. Result： Before treatment, the suPAR, CRP, WBC and PCT levels in patients with CAP were significantly higher than those in the control group, after treatment, the suPAR, CRP, WBC and PCT levels of CAP patients were lower than before treatment, the differences above were all statistically significant （ P〈0.01 ） .The hospital stays, CURB-65 score, APACHE Ⅱ score and the suPAR, CRP, WBC, PCT levels in the SCAP patients were much higher than those in the NSCAP patients, the differences were all statistically significant （P〈0.01） .The plasma levels of suPAR was correlated with the CURB-65 score, APACHE ]l score, length of hospital stay and levels of CRP, PCT.Conclusion： suPAR may play a role in the diagnosis and clinical assessment of the severity of CAP, it has a certain value in guiding therapeutic.