蛋白质芯片技术的临床应用新进展

The Latest Advances of Clinical Application on Protein Chip Technology

近年来,生物芯片技术日趋成熟,这其中,蛋白质芯片技术以其自动化、微型化、高灵敏度、高通量、高特异性等优点,被广泛地应用于蛋白质组学的研究中,并发挥着越来越大的作用。同时,由于此技术能快速、准确地找到细胞与组织在不同环境与状态下蛋白质表达的差异,因此在肿瘤、传染性疾病以及自身免疫性疾病的早期诊断中具有巨大的应用潜能。本文对蛋白质芯片技术的原理、分类与其在临床中的最新应用进展作一总结。

In recent years, biochip technology becomes more mature.Among these, the protein chip technology is playing an increasingly important role in proteomies research for its advantages of automation, miniaturization, high sensitivity, high-throughput and high specificity.Meanwhile, because this technology can quickly and accurately find the difference of protein expression of cells and tissues in different environments and state, it has enormous application~ potentiality in the early diagnosis of cancer, infectious diseases and autoimmune diseases.This paper makes a summary on the principle and classification of protein chip technology and the progress in its latest clinical application.