卡培他滨联合奥沙利铂治疗晚期结肠癌的临床疗效观察

Clinical Curative Effect of Xeloda Regimen With Oxaliplatin on Patients With Advanced Colon Cancer

目的：观察卡培他滨加用奥沙利铂联合治疗晚期结肠癌的临床疗效和毒副作用。方法给予36例晚期结肠癌患者卡培他滨1250 mg/m2日两次口服，第1～14 d，奥沙利铂130 mg/m2，第1 d静滴3 h，21 d为1个疗程周期，2个疗程以上做疗效评价。结果36例均可评价疗效， CR3例，PR18例，RR58.3%；毒副作用主要为恶心、呕吐、腹泻、口腔溃疡、末梢神经异常及骨髓抑制，大多数为Ⅰ～Ⅱ度。结论卡培他滨加用奥沙利铂联合治疗晚期结肠癌临床疗效肯定，且患者耐受性较好。

Objective To observe the clinical efficacy and tolerability of xeloda with oxaliplatin on advanced colon cancer.MethodsThirty-six patients with advanced colon cancer were treated with xeloda 1 250 mg/m2 po on the first day to the 14 day and oxaliplatin 130 mg/m2 ivgtt,on the first 21 days for a period of treatment cycle. More than 2 courses of curative effect were evaluated. Results Thirty-six cases evaluated curative effect,CR 3 cases,19 cases of PR. The overal response rate was 61.1%. Toxicity mainly were grade Ⅰ～Ⅱ,including nausea vomiting,diarrhea,oral ulcer,bone marrow suppression,and peripheral nerve abnormalities.Conclusion Xeloda regimen combined with oxaliplatin into curative effect on treatment of advanced colorectal cancer,and patient tolerance is good.