糖尿病肾病患者血清β_2微球蛋白检验的临床价值

The Clinical Value of Serum β_2 Microglobulin in Patients With Diabetic Nephropathy Inspection

目的：对糖尿病肾病患者血清β2微球蛋白检验的临床价值进行评价分析，为今后的临床检验工作提供有价值的参考信息。方法抽取2013年5月～2015年5月我院收治的获得临床明确诊断的糖尿病患者199例，其中糖尿病肾病患者79例，定义为观察组，无肾病、酮症酸中毒、严重心肝肾疾病糖尿病者120例，定义为对照组，另抽取同期健康体检者60例作为健康组。对这三组受试者展开血清β2微球蛋白检验，并对检验结果进行对比分析。结果观察组患者血清β2微球蛋白水平与异常率较对照组和健康组比较升高（P＜0.05）；糖尿病肾病患者病程≥5年者血清β2微球蛋白水平及异常率较病程＜5年者升高（P＜0.05）。结论血清β2微球蛋白在糖尿病肾病早期诊断中具有重要意义，可作为一项重要的敏感指标。

Objective Clinical value of serum β2 microglobulin test was evaluated in patients with diabetic nephropathy analysis provides valuable reference information for future clinical laboratory work.Methods Extraction between May 2013 to May 2015 in our hospital to obtain the clinical diagnosis of diabetes 199 cases,including 79 cases of patients with diabetic nephropathy,defined as the observation group,without nephropathy,ketoacidosis, severe heart and liver 120 cases of diabetic kidney disease,defined as a control group,and the other to extract the same period 60 cases of healthy people as a health group. Expand these three groups of subjects serum β2 microglobulin inspection,and test results were analyzed.ResultsThere were abnormal serum β2microglobulin rate than the control group and the healthy group were significantly increased（P〈 0.05）compare occurrence, duration of diabetes,kidney disease≥5 years serum β2-microglobulin levels and abnormal rate than duration〈 5 years was significantly increased（P〈 0.05）. ConclusionSerum β2-microglobulin is important in the early diagnosis of diabetic nephropathy can be used as a sensitive indicator of an important concern.