曲伏前列素联合卡替洛尔对原发性闭角型青光眼患者术后高眼压的降压效果分析

Antihypertensive effect analysis of travoprost combined carteolol in the treatment of high intraocular pressure of primary angle closure glaucoma postoperative

目的研究曲伏前列素联合卡替洛尔对原发性闭角型青光眼（PAGG）患者术后高眼压的降压效果。方法选择2012年4月∽2013年4月在我院接受治疗的PACG患者64例（64只眼）作为研究对象。根据随机数字表法随机分成曲伏前列素组及卡替洛尔组两组,曲伏前列素组使用0.004%的曲伏前列素实施治疗,卡替洛尔组使用2%的卡替洛尔实施治疗,对比两组治疗前后的眼压变化情况,两组治疗前后眼压差值及治疗后眼压下降的百分率,两组程度各异的前房角开放者治疗前后眼压差值及治疗后眼压下降的百分率。结果两组治疗后的眼压值均分别显著低于各组治疗前,差异有统计学意义（P〈0.05）。但两组治疗前后的组间眼压值相比,差异无统计学意义（P〉0.05）。曲伏前列素组治疗前后眼压差值与治疗后眼压下降的百分率均显著大于卡替洛尔组,差异有统计学意义（P〈0.05）。两组程度各异的前房角开放者治疗前后眼压差值及治疗后眼压下降的百分率差异无统计学意义（P〉0.05）。根据Spearman法分析相关性可知,治疗前后眼压差值及治疗后眼压下降的百分率与前房角开放程度均无明显相关性。结论曲伏前列素与卡替洛尔均可用于降低PACG患者术后的高眼压,但曲伏前列素的药效更佳,值得在临床上推广应用。

Objective To investigate antihypertensive effect analysis of travoprost combined carteolol in the treatment of high intraocular pressure of primary angle closure glaucoma patients after operation.Methods 64 patients（64 eyes）with PACG from April 2012 to April 2013 to accept the treatment in our hospital as the research object.According to the figures were randomly divided into a travoprost group and a carteolol group,the travoprost group was used 0.004% travoprost for treatment,the carteolol group was used 2% carteolol for treatment,intraocular pressure changes before and after treatment,percentage between the two groups before and after treatment and after treatment of intraocular pressure difference of intraocular pressure drop,the percentage of two groups of varying degrees of anterior chamber angle open patients before and after intraocular pressure difference after treatment and intraocular pressure drop were compared. Results Intraocular pressure after the treatment in the two groups was significantly lower than the values of each group before treatment, the difference was statistically significant（P〈0.05）.But the two groups before and after treatment between the groups compared with intraocular pressure value,the differences were not statistically significant（P〉0.05）.The percentage of travoprost group before and after treatment, intraocular pressure difference and intraocular pressure decreased after treatment were significantly higher than that in the control group,the difference was statistically significant（P〈0.05）.The percentage difference between the two groups with different levels of anterior chamber angle open patients before and after intraocular pressure difference and intraocular pressure decreased after treatment had no statistical significance（P〉0.05）.According to correlation analysis showed that Spearman method,the percentage of anterior chamber intraocular pressure difference before and after treatment and after treatment and the degree of opening of the intraocular pressure decreased angle had no obvious correlation. ConclusionTravoprost and carteolol can be used to reduce the high intraocular pressure in patients with PACG after operation, but the travoprost effect is better,and it is worthy of clinical application.