补气中药治疗癌性疲劳随机对照临床研究文献Meta分析

Meta-analysis of randomized controlled trail research literature of traditional Chinese medicine for cancer telated fatigue

目的运用Meta分析的方法,评价中医药补气药治疗癌性疲劳的临床疗效。为癌性疲劳的中医药治疗提供科学依据。方法以"癌性疲劳"相关词汇,"中药"、"中医药"、"草本植物"、"替代治疗"、"姑息治疗"等为关键词,在Pub Med、Cochrane图书馆、中国知网、维普中文科技期刊数据库、万方数据库、中国生物医学文摘进行1994-2014年间相关的随机对照试验(RCT)文献搜索。文献资料按Cochrane推荐的Cochrane风险偏倚评估工具进行评估。并运用Rev Man5.3统计软件进行Meta分析。结果共纳入文献19篇。英文文献4篇,中文文献15篇,共1 904例患者。Meta分析结果显示:试验组和对照组在治疗有效率[RR=1.72,95%CI(1.55,1.92)]、BFI量表评分[RR=1.92,95%CI(1.61,2.29)]、中医症状评分[RR=1.59,95%CI(1.27,1.99)]方面的差异具有统计学意义(P<0.05)。结论现有证据表明,中药补气药在改善癌性疲劳患者疲乏状态及生活质量、中医症状方面具有统计学意义。但尚需大规模、多中心、随机对照试验进一步验证。

Objective According meta-anlysis to asses tonic medicine in the treatment of cancer related fatigue（CRF）.To provide the scientific basis for Chinese medicine treatment of CRF.Methods “cancer related fatigue”,“Chinese herb”,“traditional Chinese medicine”,“botanicals”,“complementary medicine”,“palliative medicine”as keywords,We searched PubMed,the Co-chrane library,Cnki,Vip,Wanfang med online,Chinese biomedical literature on disc（CBM）of relevant randomized controlled trail （RCT）literature in 1994 -2014.The quality of RCT was assessed according to “the cochrane collaboration′s tool for assessing risk of bias”,which recommended by the cochrane library.Meta-anlysis were conducted with the cochrane collaboration′s RevMan 5.3.Results A total of nineteen literatures,involving 1904 patients with CRF.The results of meta-analysis showed that the experimental group and the control group have significant differences in the effective rate[RR =1.72,95%CI（1.55,1.92）],Brief fatigue inventory[RR =1.92,95%CI（1.61,2.29）],Traditional-Chinese-medicine-symtom-score system[RR =1.59,95%CI（1.27,1.99）]（P 〈0.05）. Conclusion The evidence currently available indicates that Tonic medicine had a statistically significant Improve traditional Chinese medicine symtom and the quality of life of patients with CRF.But further large scale,high quality RCTs are needed.