中国人群输精管结扎术不增加前列腺癌发病风险:Meta分析

Vasectomy does not increase the risk of prostate cancer in Chinese men: A meta-analysis

目的：探讨中国人群输精管结扎术与前列腺癌发病间的相关性。方法：系统检索3个中文文献数据库（CNKI、万方、维普）及3个英文文献数据库（Pud Med、Embase、Cochrane Library）截至2014年12月之前发表的有关中国人群输精管结扎术与前列腺癌关系的文献。由两位研究者独立按纳入和排除标准筛选文献,进行质量评价和数据提取,并采用STATA 12.0软件进行Meta分析。结果：共纳入合格的研究文献9篇,包括前列腺癌病例1 202例,对照4 496例。采用随机效应模型合并分析后的结果未发现中国人群输精管结扎术与前列腺癌相关（OR=1.05;95%CI,0.62～1.79）,且异质性明显（P〈0.001,I2=85.7%）。尚不能认为目前纳入的研究存在发表偏倚（Egger,P=0.824;Begg,P=0.348）。结论：Meta分析结果提示中国人群输精管结扎术不会增加前列腺癌的发病风险。

Objective： To investigate the correlation of vasectomy with the risk of prostate cancer in Chinese men. Methods ： We systematically searched the databases CNKI, VIP, Wanfang, PubMed, Embase, and Cochrane Library for the literature relating the relationship between vasectomy and the risk of prostate cancer in Chinese males up to December 2014. According to the inclusion and exclusion criteria, two investigators independently selected the eligible publications, evaluated their quality, and extracted relevant information, followed by a meta-analysis with the software STATA 12.0. Results： Nine studies were included in the analysis invol- ving 1 202 cases of prostate cancer and 4 496 controls. Random-effect model analysis revealed no statistically significant correlation between vasectomy and the risk of prostate cancer （OR = 1.05; 95% CI 0.62 - 1.79 ）, with an obvious heterogeneity （P 〈 0. 001, 12 = 85.7% ）. No significant publication bias was found among the included studies （Egger, P = 0. 824; Begg, P =- 0. 348）. Conclusion ： The results of our meta-analysis do not support the association of vasectomy with the increased risk of prostate cancer in Chinese population.