S100A7蛋白在口腔黏膜下纤维性变治疗前后组织中的表达

Expressions of S100A7 in oral submucous fibrosis before and after treatment

目的观察口腔黏膜下纤维性变(OSF)患者治疗前后的颊黏膜和正常颊黏膜中S100A7的表达。方法收集10例正常颊黏膜组织和10例OSF患者经丹参联合小剂量曲安奈德局部注射治疗前后的颊黏膜组织,用免疫组织化学方法检测其S100A7的表达,比较并分析其表达差异。结果 1)治疗后OSF患者S100A7的阳性率为30%,表达量计分为(2.30±0.82)分,均低于治疗前的阳性率(90%)和表达量计分值(4.20±1.14)分,且差异有统计学意义(P<0.05)。2)治疗后OSF患者和正常黏膜的S100A7阳性率分别为30%、0,差异无统计学意义(P>0.05);但OSF治疗后S100A7的表达量计分值(2.30±0.82)分,高于正常黏膜的表达量计分(0.60±0.52)分,差异有统计学意义(P<0.05)。结论丹参联合小剂量曲安奈德局部注射治疗OSF能下调S100A7的表达,且S100A7可作为评价OSF疗效的指标之一。

Objective To check the expressions of S100A7 in the buccal mucosa of oral submucous fibrosis（OSF） patients before and after treatment and normal buccal mucosa. Methods Buccal mucosa specimens of 10 normal people and 10 OSF patients （before and after treatment by local injections of triamcinolone acetonide acetate and salvia miltiorrhiza） are collected, their expressions of S 100A7 checked by immunohistochemistry and the data analyzed statistically. Results 1） After the treatment, S 100A7 positive rate of patients with OSF was 30%, expression of scoring is （2.30±0.82） points, are lower than before treatment amount of positive rate（90%） and express the scoring value（4.20±1.14）, and the difference was statistically significant（P〈0.05）. 2） S 100A7 positive rate of OSF patients after the treatment, and normal mucosa were 30%, 0, respectively, there was no statistically significant difference（P〉0.05）; but the expression of SI00A7 with OSF after treatment score values（2.30±0.82）, is higher than that of normal mucosa express quantity scoring （0.60±0.52）, the difference was statistically significant（P〈0.05）. Conclusion Treatment can downregulate S100A7 expression, suggesting a promising biomarker to evaluate OSF prognosis.