摘要
正畸矫治器多为金属制品且含多种金属成分,其中的镍、铬、铜和银等离子含量过高对细胞有一定的影响,因此对其生物安全性检测必不可少。镍含量小于5%的金属托槽同样具有细胞毒性,影响细胞的形态和增殖。铜和锌离子颊管也具有较强的细胞毒性作用。影响金属离子释放的主要因素有金属的组成、表面结构和蛋白质以及浸提液类型、浸提时间、浸提液p H等。目前,彗星试验和微核试验是常用的细胞基因毒性检测方法,二者用以检测细胞的基因毒性,可起到互补的作用。本文就正畸金属矫治器的毒性,正畸金属矫治器的离子释放,正畸金属材料的细胞毒性和基因毒性等研究进展作一综述,旨在为后续研究提供参考。
Most orthodontic appliances are metal and contain many metal elements, such as nickel, chromium, copper, and silver, which have been confirmed to be cytotoxic at high concentrations. Thus, the biosecurity of these metals needs to be tested. Metal brackets with concentrations of less than 5% nickel have also been confirmed to be cytotoxic. These brackets, such as metal buccal tube with copper and zinc, affect cell morphology and proliferation. The factors affecting the release of metal ions are as follows： metal elements, surface structure, protein, immersing category, immersing time, and immersing potential of hydrogen. Currently, the complementary methods of Comet and micronuclear tests are mainly used to test genotoxicity. This article aimed to discuss the cytotoxicity and genotoxicity of metal orthodontic appliances in terms of ion release, as well as study cytotoxicity and genotoxicity. This article will offer reference for others.
出处
《国际口腔医学杂志》
CAS
北大核心
2015年第5期592-596,共5页
International Journal of Stomatology
关键词
正畸金属矫治器
离子释放
细胞毒性
基因毒性
orthodontic metallicappliance
ion releasing
cytotoxicity
genotoxicity
