他汀类药物在蛛网膜下腔出血中的神经保护作用被引量：2

Neuroprotective effects of stafins in subarachnoid hemorrhage

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摘要蛛网膜下腔出血（subarachnoid hemorrhage，SAH）是一种常见的脑血管病，其残疾率和病死率均较高。业已证实，早期脑损伤（early brain inajury，EBI）和脑血管痉挛（cerebral vasospasm，CVS）是导致SAH后神经功能障碍和死亡的主要病理生理学机制。导致CVS和EBI的因素很多，包括一氧化氮、内皮素、氧合血红蛋白和促炎细胞因子等。大量动物实验和临床研究证实，他汀类药物具有神经保护作用。文章对他汀类药物在SAH中的神经保护作用及其机制进行了综述。 Subarachnoid hemorrhage （SAH） is a common cerebrovascular disease, its disability and mortality rates are higher. It has been confirmed that early brain injury （EBI） and cerebral vasospasm （CVS） are the major pathophysiological mechanisms of causing neurological dysfunction and death after SAH. There are a variety of factors of causing CVS and EBI, including nitric oxide, endothelin, oxyhemoglobin, and proinflammatory cytokines. A large number of animal experiments and clinical research have confirmed that statins have neuroprotective effects. This article reviews the neuroprotective effects and its mechanisms of statins in SAH.

作者陈军辉王玉海

机构地区解放军第一

出处《国际脑血管病杂志》 2015年第7期554-558,共5页 International Journal of Cerebrovascular Diseases

关键词蛛网膜下腔出血羟甲基戊二酰基COA还原酶抑制剂血管痉挛颅内神经保护药 Subarachnoid Hemorrhage Hydroxymethylglutaryl-CoA Reductase Intu＇bitors Vasospasm,Intracranial Neuroprotective Agents

分类号 R743.35 [医药卫生—神经病学与精神病学]

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