5-氨基酮戊酸光动力疗法治疗中重度痤疮的临床疗效观察

The clinical research of three treatment methods of 5-aminolevulinic acid photodynamic therapy for moderate to severe acne

目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)的不同治疗方案治疗中重度痤疮的有效性与安全性。方法 60例中重度痤疮患者,随机分为3组,分别接受1个基础疗程、1个基础疗程联合1个维持疗程和2个基础疗程治疗,治疗结束后1、3、6、12个月对患者进行访视,记录皮损消退情况及不良反应。结果 3个月后3组患者治疗的有效率分别为80%、90%和88.2%;6个月后3组患者治疗的有效率分别为55%、85%和88.2%。12个月后3组复发率分别为60%、20%和52.9%。结论 ALA-PDT治疗中重度痤疮安全、有效。2个基础疗程和1个基础疗程联合1个维持疗程方案均获得较好的疗效,且基础疗程联合维持疗程的治疗复发率最低。

Objective To observe the efficacy and safety of three different methods of 5-aminolevulinic acid photodynamic therapy（ALA-PDT） to treat moderate to severe acne. Methods Sixty patients with moderate to severe acne were randomly divided into three groups and treated with different strategies. Group A were treated with one basic course. Group B were treated with one basic course and one maintaining course. Group C were treated with two basic courses. The effect and adverse reaction were evaluated on 1, 3, 6 and 12-month visit after the last treatment. Results The effective rates of three groups were 80%, 90% and 88.2%respectively on 3-month visit, and were 55%, 85%, 88.2%respectively on 6-month visit. The recurrence rates were 60%, 20% and 52.9% respectively on 12-month visit. Conclusion ALA-PDT is safe and effective for moderate to severe acne. Two basic courses or one basic course with one maintaining course were both effect but one basic course with one maintaining course has lowest recurrence rate.