胆囊癌相关基础研究进展

Gallbladder cancer： a comprehensive review on basic research

胆囊癌是胆道系统最常见的恶性肿瘤。其发现和患者就诊一般较晚，手术切除率低，疗效较差。加强胆囊癌基础研究以期改善胆囊癌的诊断和治疗非常必要。本文从胆囊癌发生、发展相关基因，胆囊癌淋巴转移机制，胆囊癌肿瘤微环境三个方面就近年来胆囊癌相关基础研究进展作一综述。

Gallbladder cancer （GBC） is the most common malignancy of the biliary tract. Most patients are diagnosed at the advanced stage, missing the optimal chance for curative surgery, thus leading to the fact that GBC is usually associated with poor prognosis. It is very crucial to strengthen the basic research on GBC, which may further improve the diagnosis and treatment. The research updates on the related genes in the initiation and progression, molecular mechanism of lymphatic metastasis, and tumor microenvironment of GBC in recent years were reviewed in this paper.