1Kranstuber AL, Del Rio C, Biesiadecki B J, et al. Advanced gly- cation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling [ J ]. Front Physiol, 2012,19 (3) :292.
2Boudina S, Sena S, O'Neill BT, et al. Reduced mitochondrial oxi- dative capacity and increased mitochondrial uncoupling impair myo- cardial energetics in obesity [ J ]. Circulation. 2005,112 ( 17 ) : 2686-2695.
3Anderson E J, Kypson AP,. Rodriguez E, et al. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human hear.[ J]. J" Am Coil Cardiol, 2009,54(20) : 1891-1898.
4Sari FR, Watanabe K. Thandavarayan RA, et al. 14-3-3 protein protects against cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis in experimental diabetes [ J ]. J Pharmacol Sci, 2010,113 (4) :325-334.
5Wu T, Dong Z, Geng J, et al. Valsartan protects against ER stress-induced myocardial apoptosis via CHOP/Puma signaling pathway in streptozotocinindced diabetic rats [ J ]. Eur J Pharm Sci, 2011 ,42(5) :496-502.
6Wold LE, Ran J. Streptozotin directly impairs cardiac contractile i function in isolated ventrular myocytes via a p38 map kinase-de- pendent oxidative stress hneehanism [ J ]. Biochem Biophys Res Commun, 2004,3-18 (4) : 1066-1071.
7Imrie H, Abbas A, Keamey M. Insulin resistance, lipotoxieity and endothelial dysfunction [J]. Bioehim Biophys Acta, 2010, 1801 (3) :320-326.
9Van den Bergh A, Vanderper A, Vangheluwe P, et al. Dyslipidae- mia in type II diabetic mice does not aggravate contractile impair- ment but increases ventricular stiffness [ J ]. Cardiovasc Res, 2008,77(2) :371-379.
10Pereira L, Matthes J, Schuster I, et al. Mechanisms of Ca2 tran- sient decrease in cardiomyopathy of db/db type 2 diabetic mice [J]. Diabetes, 2006,55(3):608-615.
2Greer J J, Ware DP, Lefer DJ. Myocardial infarction and heart fail- ure inthe db/db diabetic mouse[J]. Am J Physiol Heart Circ Physi- ol, 2006,290( 1 ) :146-153.
3Aasum E, Hafstad AD, Severson DL, et al. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice [ J ]. Diabetes, 2003,52 ( 2 ) :434-441.
4Cesario DA, Brar R, Shivkumar K. Alterations in ion channel phys- iology in diabetic cardiomyopathy[ J]. Endocrinol Metab Clin North Am, 2006,35(3) :601- 610.
5Trost SU, Belke DD, Bluhm WF, et al. Overexpression of the sar- coplasmic reticulum Ca^2+ -ATPase improves myocardial contractility in diabetic cardiomyopathy [ J]. Diabetes, 2002,51 (4) : 1166 - 1171.
6Liu X, Suzuki H, Sethi R, et al. Blockade of the renin-angiotensin system attenuates sarcolemma and sarcoplasmic reticulum remodeling in chronic diabetes[J]. Ann N Y Acad Sci, 2006,1084(4) :141- 154.
7Yaras N, Bilginoglu A, Vassort G, et al. Restoration of diabetesin- dueed abnormal local Ca2 + release in cardiomyocytes by angiotensin Ⅱ receptor blockade[J]. Am J Physiol Heart Cite Physiol, 2007, 292(2) :912-920.
8Shen X, Zheng S, Metreveli NS, et al. Protection of cardiacmito- ehondria by overexpression of MnSOD reduces diabetic eardiomyopa- thy[J]. Diabetes, 2006,55(3) :798-805.
9Coort SL, Hasselbaink DM, Koonen DP, et al. Enhanced sar- colemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats [ J ]. Diabetes, 2004,53 ( 7 ) : 1655- 1663.
10Oakes ND, Thalen P, Aasum E, et al. Cardiac metabolism in mice: tracer method developmentsand in vivo application revealing profound metabolic inflexibilityin diabetes [ J ]. Am J Physiol Endo- crinol Metab, 2006,290 (5) : E870-E881.
1MOZAFFARIAN D. Dietary and Policy Priorities for CardiovascularDisease, Diabetes, and Obesity : A Comprehensive Review [J]. Circulation,2016,133(2) :187-225.
2ZHANG X,WEI X, LIANG Y,et al. Differential changes of leftventricular myocardial deformation in diabetic patients with controlledand uncontrolled blood glucose : a three - dimensionalspeckle - tracking echocardiography - based study [J]. J Am SocEchocardiogr,2013,26(5) :499 -506.
3TADIC M, CELIC V , CUSPIDI C, et al. Right heart mechanics inuntreated normotensive patients with prediabetes and type 2 diabetesmellitus: a two - and three - dimensional echocardiographicstudy[J]. J Am Soc Echocardiogr,2015 ,28(3) :317 -327.
4TAYYARECI Y, YURDAKUL S,TAYYARECI G,et al. Impact ofmyocardial acceleration during isovolumic contraction in evaluatingsubclinical right ventricular systolic dysfunction in type 2 diabetesmellitus patients [J]. Echocardiography, 2010,27 ( 10 ) : 1211 -1218.
5Kim OK, Jun W, Lee J. Mechanism of ER stress and inflammation for hepatic insulin resistance in obesity [ J ]. Ann Nutr Metab, 2015,64(4) :218-227.
6Anelli T, Sitia R. Protein quality control in the early secretory pathway[J]. EMBO J, 2008,27(2) :315-327.
7Chistiakov DA, Sobenin IA, Orekhov AN, et al. Role of endoplas- mic reticulum stress in atherosclerosis and diabetic macrovascular complications [ J]. Biomed Res Int, 2014,2014(3) :610140.
8Liu X, Xu Q, Wang X, et al. Irbesartan ameliorates diabetic cardio- myopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model[J]. Pharmacol Res, 2015,93(3) :43-51.
9Gan R, Hu G, Zhao Y, et al. Post-conditioning protecting rat car- diomyocytes from apoptosis via attenuating calcium-sensing recep- tor-induced endo ( sareo ) plasmic reticulum stress [ J ]. Mol Cell Biochem, 2012, 361 ( 1-2 ) : 123-134.
10Shi FH, Cheng YS, Dai DZ, et al. Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argirein [ J ]. Naunyn Schmiede- bergs Arch Pharmacol, 2013, 386(6) :521-531.