低强度脉冲超声波促进脊柱融合的研究进展

Low-intensity pulsed ultrasound stimulations promoting spinal fusion:recent progress

脊柱融合术是重建脊柱稳定性的常用手术方案,但是面临融合失败、假关节形成等并发症。研究发现低强度脉冲超声波(low-intensity pulsed ultrasound,LIPUS)可以明显促进脊柱融合,减少融合失败发生率,其病理基础为软骨细胞增殖和分化的软骨内成骨。进一步研究发现,LIPUS不仅可以直接促进间充质干细胞向成骨区域转移,促进成骨细胞和软骨细胞增殖、分化,同时,动物实验还证实LIPUS可以促进成骨区域血管新生和神经支配,进而促进植骨融合。

Spinal fusion is the common procedure to restore the stability of spine.However,fusion failure and pseudoarthrosis are frequent.Previous studies have found that low-intensity pulsed ultrasound（LIPUS）can accelerate spinal fusion and reduce fusion failure,with endochondral ossification being the main pathological process.Further investigations have revealed that LIPUS can directly promote the migration,proliferation,osteogenesis,and chondrogenesis of mesenchymal cells.Moreover,LIPUS is indicated to accelerate angiogenesis and innervation coupling,finally promoting spinal fusion.