系统性红斑狼疮伴中重度血小板减少的临床特征

Clinical Characteristics of Systemic Lupus Erythematosus with Moderate or Severe Thrombocytopenia

目的:探讨系统性红斑狼疮伴中重度血小板减少患者的临床特征。方法:收集20例系统性红斑狼疮伴中重度血小板减少患者的临床资料,并与20例血小板正常的系统性红斑狼疮患者对比,比较两组患者实验室检查结果、临床症状和体征及疾病活动度的差异。结果:两组患者在发热、皮疹、关节炎等临床症状和体征,抗ds-DNA、抗NUC、抗HIS、抗U1RNP、抗SSA、抗SSB、抗C1q抗体阳性率及疾病活动度等方面比较,差异无统计学意义(P>0.05);但系统性红斑狼疮伴中重度血小板减少患者白细胞计数、血红蛋白浓度及补体C3水平更低,抗磷脂抗体阳性率更高,差异有统计学意义(P<0.05)。结论:系统性红斑狼疮伴中重度血小板减少患者较系统性红斑狼疮血小板正常患者白细胞计数、血红蛋白浓度及补体C3水平更低,抗磷脂抗体阳性率更高。

Objective：To investigate the clinical characteristics of systemic lupus erythematosus with moderate or severe thrombocytopenia.Methods：Clinical data of 20 cases of systemic lupus erythematosus with moderate or severe thrombocytopenia were collected,which were compared with another 20 cases of system lupus erythematosus with normal platelets on the aspects of laboratory findings,clinical symptoms,signs,and the differences of disease activity.Results：On the aspects of clinical symptoms and signs such as fever, rash and arthritis,anti ds-DNA,anti NUC,anti HIS,anti U1RNP, anti SSA,anti SSB,anti Clq antibodies positive rate and disease activity, the differences between the two groups were not statistically significant （ P 〉 0.05 ） ,but for those of systemic lupus erythematosus with medium or severe thrombocytopenia,white blood cell count,hemoglobin concentration and complement C3 concentration were lower, and the positive rate of anti phospholipid antibody was higher, the difference being statistically significant （ P 〈 0.05 ） .Conclusion：For patients with systemic lupus erythematosus with moderate or severe thrombocytopenia,white blood cell count,hemoglobin concentration and complement C3 concentration were lower, and the positive rate of anti phospholipid antibody was higher than those with normal platelets.