肿瘤患者金黄色葡萄球菌感染临床分析

Clinical analysis of staphylococcus aureus infection in patients with cancer

目的对肿瘤患者金黄色葡萄球菌感染调查并进行分析。方法 2014年1~12月在我院治疗的肿瘤患者61745例,其中恶性肿瘤2100例,良性肿瘤59645例。感染金黄色葡萄球菌272株,其中耐甲氧西林金黄色葡萄球菌（MRSA）220株,甲氧西林敏感金黄色葡萄球菌（MSSA）52株。按培养标本、病原、疾病、季节进行分组比较。结果恶性肿瘤与留置导管、化疗患者的耐甲氧西林金黄色葡萄球菌（MRSA）感染率高（P〈0.05）。痰标本中MRSA检出率最高（P〈0.05）。冬季是MRSA感染的高发季节（P〈0.05）。结论恶性肿瘤患者中金黄色葡萄球菌感染率高,临床感染的患者应按金黄色葡萄球菌分布特点积极预防及治疗以降低耐药率。

Objective To investigate and analyze staphylococcus aureus infection in the patients with cancer. Methods A total of 61745 cases of patients were treated in our hospital from January to December 2014, including 2100 cases with malignant tumor and 59645 cases with benign tumor. 272 strains of staphylococcus aureus were selected, including220 strains of methicillin-resistant staphylococcus aureus（MRSA） and 52 strains of methicillin-sensitive staphylococcus aureus（MSSA）. They were compared by specimen, pathogen, disease and season. Results The patients with malignant tumor, with indwelling catheter or receiving chemotherapy had higher MRSA infection rates（P〈0.05）. Of the sputum specimens, the detection rate of MRSA was the highest（P〈0.05）. MRSA was highly prevalent in winter（P〈0.05）. Conclusion The patients with malignant tumor have a high infection rate of staphylococcus aureus. Positive prevention and treatment of the infected clinical patients based on the distribution features of staphylococcus aureus can reduce the drug resistance rate.