急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清胰岛素样生长因子-1的相关性分析

Analysis on the correlation between the stability of carotid atherosclerostic plaque and serum insulin-like growth factor-1 in patients with acute cerebral infarction

目的分析急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清胰岛素样生长因子-1（IGF-1）的相关性。方法选取2012年1月~2014年1月期间我院接受治疗的100例急性脑梗死患者为观察组,并选取同期到我院来进行健康检查的50例健康志愿者作为对照组。采用ELISA法对研究对象的IGF-1的水平进行测定,并采用颈动脉彩超对研究对象进行检查,根据检查结果分为斑块稳定组、斑块不稳定组和无斑块组。结果观察组患者的斑块不稳定、斑块稳定、无斑块和总斑块检出率分别为42.0%、25.0%、33.0%和67.0%,对照组分别为8.0%、18.0%、74.0%和26.0%,差异具有统计学意义（P〈0.05）。无斑块组血清IGF-1水平显著高于斑块稳定组,无斑块组和斑块稳定组的血清IGF-1显著高于斑块不稳定组,差异具有统计学意义（P〈0.05）。多组间的比较为单因素方差分析,F=4.158,P=0.006。斑块稳定组和斑块不稳定组两组患者治疗前的神经功能和精神状态差异无统计学意义（P〉0.05）,治疗后斑块稳定组患者的神经功能和精神状态显著优于斑块不稳定组,差异具有统计学意义（P〈0.05）。结论脑梗死患者具有较高的颈动脉粥样硬化斑块发生率,稳定性颈动脉粥样硬化斑块患者的血清IGF-1水平较高,血清IGF-1水平的减少与不稳定性颈动脉粥样硬化斑块形成有密切联系。

Objective To analyze the correlation between the stability of carotid atherosclerostic plaque and serum in-sulin-like growth factor-1 （IGF-1） in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction who were admitted to our hospital from January 2012 to January 2014 were selected as an observa-tion group, and 50 healthy volunteers who received physical examination in our hospital at the same period of time were selected as a control group. ELISA method was applied to measure the level of serum IGF-1 in subjects, and carotid color ultrasonography was applied for examination in subjects. On the basis of the results of examination, the subjects were divided into stable plaque group, instable plaque group and plaque-free group. Results The detection rate of in-stable plaque, stable plaque, plaque-free and total plaque detection rate in the observation group were 42.0%, 25.0%, 33.0% and 67.0% respectively, in the control group were 8.0%, 18.0%, 74.0% and 26.0%. The differences were statis-tically significant （P〈0.05）. Serum IGF-1 level in the plaque-free group was significantly higher than that in the stable plaque group, and serum IGF-1 level in the plaque-free group and stable plaque group was significantly higher than that in the instable plaque group. The differences were statistically significant （P〈0.05）. One-way analysis of variance was applied in the comparison between multiple groups, F=4.158, P=0.006. The differences of neurological function and mental states before the treatment in the stable plaque group and instable plaque group were not statistically signifi-cant （P〉0.05）, and the neurological function and mental states after the treatment in the stable plaque group were signif-icantly better than those in the instable plaque group. The differences were statistically significant （P〈0.05）. Conclusion Patients with cerebral infarction have relatively higher incidence of carotid atherosclerostic plaque, and patients with stable carotid atherosclerostic plaque have higher serum IGF-1 level. The reduction of serum IGF-1 level is closely correlated with the formation of instable carotid atherosclerostic plaque.