摘要
目的探讨不同剂量立普妥对老年高血压患者血脂、颈动脉粥样硬化的疗效。方法选取2012年1月~2013年12月于我社区门诊进行治疗的高血压并明确有颈动脉粥样硬化的50例老年患者为研究对象,将其随机分为A组和B组各25例,A组采用立普妥（10 mg/日）进行治疗,B组采用立普妥（20 mg/日）进行治疗,将两组患者治疗前及治疗后6个月的颈动脉内膜中层厚度、斑块总面积及斑块积分、血清HDL-C、LDL-C、TG、TC进行比较。结果 A组治疗后6个月的颈动脉内膜中层厚度、斑块总面积及斑块积分、血清HDL-C、血清LDL-C、TG、TC与B组比较无统计学意义（P〉0.05）。结论老年高血压患者无论使用立普妥10 mg/日还是20 mg/日对颈动脉粥样硬化和血脂的改善无明显差别。
Objective To investigate the efficacy for different doses of Liptor on serum lipid ,carotid atherosclerosis of elderly hypertensive patients. Methods A total of 50 cases of elderly patients of Lishi Road community in the outpa-tient department for treatment of high blood pressure and carotid atherosclerosis from January 2012 to December 2013 were chosen as the research object.They were randomly divided into group A with 25 cases and group B with 25 cases. Patients in group A were given oral Liptor 10mg once daily and patients in group B were given oral Liptor 20 mg once daily. The carotid artery intima-media thickness,plaque block area and plaque score,serum HDL-C, LDL-C,TG,TC for the two groups before treatment and 6 months after treatment were compared. Results The carotid artery intima-media thickness,plaque block area and plaque score, serum HDL-C,LDL-C,TG,TC were not significantly different between the two groups 6 months after treatment （P〉0.05）. Conclusion No significant difference has been found in Liptor at doses of 10 mg/d or 20 mg/d on serum lipid,carotid atherosclerosis of elderly hypertensive patients.
出处
《中国现代医生》
2015年第19期96-99,共4页
China Modern Doctor
