安徽省合肥市农村人群睡眠质量与认知功能的相关性分析

Correlation analysis of sleep quality and cognitive function among the Hefei rural population in Anhui Province

目的探究安徽省合肥市农村中老年人群睡眠质量指数与认知功能之间的关系。方法 2014年5月在安徽省合肥农村地区进行流行病学调查。分别利用匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)以及简易精神状态量表(mini-mental state examination,MMSE)对人群完成相应睡眠质量和认知功能的测查。采用多元线性回归分析两者间的相关性。结果共有777名人群完成所有资料收集,纳入到此次横断面研究。多元线性回归分析提示,在校正年龄、性别、教育水平、婚姻状况、血压、空腹血糖、血脂、白蛋白、尿酸、尿素氮、肌酐、抑郁得分、体重指数、吸烟史、体力劳动以及既往疾病史等后,以PSQI总得分的第一分位组(25.5±4.7)作为参照,PSQI总得分的第三分位组中人群MMSE得分降低(23.3±5.3,P<0.001);分层分析结果显示在女性和年龄大于60岁的人群中PSQI总得分与MMSE得分呈负相关(β=-0.14,sx珋=0.05,P=0.004;β=-0.19,sx珋=0.06,P=0.002)。结论本研究提示在合肥农村地区人群尤其是女性和60岁以上人群中睡眠质量与认知功能呈现显著负相关。

Objective To investigate the relationship between sleep quality index and cognitive function in the Hefei rural population in Anhui Province. Methods An epidemiological survey was conducted in May,2014 among rural areas of Hefei,Anhui Province. During the survey,the Pittsburgh sleep quality index（ PSQI） and Mini-mental state examination（ MMSE） were administered to all participants in order to evaluate the sleep quality and cognitive function. The multiple linear regression analysis was conducted to determine the independent relationship between them. Results A total of777 participants who had completed all the data collection were included in the our cross-sectional analyses.（ 1） Results from multiple linear regression analysis adjusted for age,sex,educational level,marital status,blood pressure,blood glucose,blood lipids,albumin,uric acid,blood urea nitrogen,creatinine,depression score,body mass index,smoking history,physical labor and the past medical history showed that the average MMSE scores of participants in the third tertile of PSQI global scores（ 23. 3 ± 5. 3,P〈0. 001） decreased significantly compared with participants in the first tertile（ 25. 5± 4. 7）;（ 2） The stratified analyses showed that increased PSQI global scores were significantly associated with lower MMSE scores among the female participants and those of the age over 60 years（ β =- 0. 14,sx= 0. 05,P = 0. 004; β =- 0. 19,sx= 0. 06,P = 0. 002）. Conclusions The study showed that sleep quality was negatively associated with the cognitive function among the rural population in Hefei,Anhui Province,especially the female participants and participants older than 60 years.