摘要
4-氨基-2-氟苯酚是重要的医药化工中间体。本研究以1,2-二氟-4-硝基苯(2)为原料,经选择性水解反应生成2-氟-4-硝基苯酚(3),3与水合肼在三氯化铁催化下还原生成4-氨基-2-氟苯酚(1)。该方法设计巧妙,具有操作简便、条件温和、原料易得的特点,两步总收率达69%。
A practical method for the preparation of 4 - amino - 2 - fluorophenol （ 1 ） as a pharmaceutical intermediate has been developed. This new process was synthesized from 1, 2 - difluoro - 4 - nitrobenzene （2） via selectively hydrolysis, and the product （3） was reduced to obtain 4 - amino - 2 - fluorophenol （ 1 ） with FeCl3 catalysis. The developed method featured as convenient manipulation, mild reaction conditions, and simple starting materials, and the overall yield of two steps was about 69%.
出处
《山东化工》
CAS
2015年第16期7-8,共2页
Shandong Chemical Industry
关键词
4-氨基-2-氟苯酚
中间体
合成
还原
水合肼
4 - amino - 2 - fluorophenol
intermediate
synthesis
reduction
hydrazine hydrate
