住院双相障碍患者伴发代谢综合征情况调查

Investigation of metabolic syndrome in inpatients with bipolar disorder

目的:探讨住院双相障碍(BD)患者伴发代谢综合征(MS)情况及相关因素。方法:对231例住院BD患者(BD组)进行一般情况调查、代谢相关指标的测量,结果与147名健康对照者(NC组)比较。结果:BD组体质量指数(BMI)、腰围(WAIST)、血清三酰甘油(TG)、空腹血糖(FPG)水平、血压异常率、中心型肥胖率及MS发生率显著高于NC组,血清高密度脂蛋白(HDL)水平显著低于NC组(P<0.05或P<0.01)。BD患者中男性MS发生率(44.8%)明显高于女性(33.0%)(P<0.05);相对于非MS患者,伴有MS的患者年龄大、BD病程长,差异有统计学意义(P<0.05或P<0.01)。结论:BD患者MS发生率高,男性、年龄大、病程长为可能的危险因素。

Objective： To explore the prevalence of metabolic syndrome（ MS） and the related factors in inpatients with bipolar disorder（ BD）. Method： The general situations were surveyed and metabolism related indicators were measured in 231 BD inpatients（ BD group）; the results were compared with 147 healthy controls（ NC group）. Results： The body mass index（ BMI）,waist circumference（ WAIST）,levels of serum triglycerides（ TG）,fasting plasma glucose（ FPG）,the abnormal rates of blood pressure,rate of central obesity and the incidence of MS in BD group were significantly higher than those in the NC group; the level of serum highdensity lipoprotein（ HDL） was significantly lower than the NC group（ P〈0. 05 or P〈0. 01）. In the BD group,the incidence of MS in male（ 44. 8%） was significantly higher than female（ 33. 0%,P〈0. 05）. Compared to the BD patients without MS,the age of the patients with MS was elder and the course of BD was longer,the differences had statistical significance（ P〈0. 05 or P〈0. 01）. Conclusion： The incidence of MS in BD inpatients is higher. The risk factors may be correlated with male,elder and longer BD duration.