新生儿黄疸的治疗药物研究进展

Progress in study on therapeutic drugs against neonatal jaundice

新生儿黄疸是新生儿早期的一种生理现象,也是出生之后多种病理性疾病的临床表现之一。如不积极治疗,容易引起核黄疸等严重后遗症。药物治疗是新生儿黄疸的主要治疗手段之一。本文从抑制胆红素生成、加速胆红素转运、阻断胆红素肝肠循环、增加胆红素结合及促进胆红素排泄等不同环节,综述了新生儿黄疸的药物治疗进展,旨在为新生儿黄疸的防治及相关药物的临床合理应用提供参考。

Neonatal jaundice is a physiological phenomenon in early neonatal stage, and one of clinical symptoms of various pathological disease after birth. If not actively treated, it can cause serious sequelae such as kernicterus. Drug treatment is one of main therapeutic approaches for neonatal jaundice. This paper summarized recent progresses in therapeutic drugs against neonatal jaundice by inhibiting bilirubin generation, accelerating bilirubin transportation, blocking bilirubin enterohepatic circu- lation, increasing bilirubin conjugation and promoting bilirubin excretion. Aim of this review is to provide reference for prevention and treatment of neonatal jaundice, and to achieve rational application of related drugs.