玉屏风颗粒联合非索非那定治疗慢性荨麻疹的临床疗效及对患者生活质量的影响

Influence of Yupingfengkeli Combined with Fexofenadine on Quality of Life in Patients with Chronic Urticaria and its Therapeutic Efficacy

目的观察玉屏风颗粒联合非索非那定治疗慢性荨麻疹的临床疗效及对患者生活质量的影响。方法将84例慢性荨麻疹患者随机分为观察组(n=42例)及对照组(n=42例),对照组予非索非那定治疗,观察组在对照组的基础上加用玉屏风颗粒治疗,两组均治疗4周;检测两组治疗前后的血清IL-4,IFN-γ及Ig E水平,记录患者治疗前后VAS,LFS及UAS评分,并比较治疗第1周,2周,4周的皮肤病生活质量指数评分(DLQI)以及治疗疗效。结果观察组治疗第4周时血清IL-4和Ig E水平低于对照组,IFN-γ高于对照组(P<0.05);且治疗第4周的VAS,LFS和UAS评分显著低于对照组(P<0.05);治疗第1周,2周,4周的DLQI评分亦均低于对照组(P<0.05);治疗第1周,4周的有效率明显高于对照组(P<0.05)。结论玉屏风颗粒联合非索非那定治疗慢性荨麻疹的临床效果显著,能够明显改善患者的免疫状态和生活质量,可取得满意的综合疗效。

Objective To observe influence of Yupingfengkeli combined with fexofenadine on quality of life in patients with chronic urticaria and its therapeutic efficacy. Methods Eighty-four cases of patients with chronic urticaria were randomly divided into observation group （n = 42 cases） and control group （n = 42 cases）, control group was given treatment of fexofenadine, observation group received Yupingfengkeli particles on the basis of control group; serum IL-4, IFN-γ and IgE levels were detected before and after treatment, VAS, LFS and UAS scores were recorded before and after treatment; dermatology life quality index score （DLQI） and therapeutic efficacy were also recoded before and after 1,2 and 4 weeks treatment. Results Compared with control group, serum IL-4, IgE levels of observation group were lower after 4 weeks after treatment （P 〈 0. 05 ）, while IFN-γ level was higher （P 〈 0. 05） ; VAS score, LFS score, UAS score of observation group were sig- nificantly lower than those of control group （P 〈 0. 05 ） ; DLQI score of observation group was also lower than the control group after 1,2 and 4 weeks treatment （P 〈 0. 05） ,whereas the total effective rate of observation group was obviously higher than that of control group （P 〈 0. 05）. Conclusion Yupingfengkeli com- bined with fexofenadine is effective in treatment of chronic urticaria, and the combination therapy can obviously improve the patient＇s immune status, and to improve the quality of life of patients, and so satisfactory curative effect is obtained.