基于“方证对应”理论从临床遣方用药分析女性不孕症的证候分布

Chinese medical syndrome distribution of infertility based on prescription guided by corresponding theory of formulas and syndromes: a literature review

目的从不孕症的临床遣方用药治疗规律探讨不孕症的证候分布规律,为该病的临床治疗和科研组方用药提供依据和指导。方法计算机检索中医药治疗不孕症的相关文献,并采用内容分析法提取不孕症治疗的相关方药,并将提取的信息录入Epi Data 2.0软件数据库,采用SPSS 18.0统计软件对其方药的类型、使用频次、频率和归经进行分析,针对方药分布结果探讨不孕症的证候分布规律。结果共纳入文献144篇,出现频率较高的中药类型依次为活血药、补阳药、补血药、补气药、清热药、理气药、补阴药、利水渗湿药、解表药、温里药和化痰药。出现频率较高的药物归经为肝、肾、脾、胃、肺、心。结论基于方证对应理论,以方测证得出的不孕症常见证候主要以肝气郁结证、肾气虚证、肾阳虚证、肾阴虚证、胞宫湿热证、瘀阻胞宫证、肝肾阴虚证、肝郁脾虚证、脾胃气虚证、痰凝胞宫证为主。

Objective To explore the rules of Chinese medical syndrome distribution of infertility based on the analysis of prescription, so as to provide scientific basis for clinical practice and research. Meth- ods A literature searching of VIP, Wangfang data, CNKI and CBM was perfornqgd. After all the formu- las and medicines extracted from the literature were input EpiData2.0 and analysed by using SPSS 18.0 software, the catagory, frequency, rate and channels were obtained. Results 144 citations were identi- fied. The use frequency of Chinese medicinal herbs ranked from high to low were drugs for invigorating blood circulation, drugs for yang-tonifying, drugs for enriching blood, drugs for qi-tonifying, drugs for clearing heat, drugs for regulating the flow of vital energy and removing obstruction toit, drugs for yin- tonifying, drugs for clearing damp and promoting diuresis, drugs for relieving exterior syndrome, drugs for warming interior and drugs for removing phlegm. The channel tropism of medicines ranked from high to low were liver meridian, kidney meridian, spleen meridian, stomach meridian, lung meridian and heart meridian. Conclusion According to the analysis of medicine types and channel tropism based on the corresponding theory of formulas and syndromes, the main syndromes of infertility were syndrome of stagnation of liver qi, syndrome of deficiency of kidney qi, syndrome of deficiency of kidney yang, syn- drome of deficiency of kidney yin, syndrome of dampness - heat in uterus, syndrome of static blood bloc- king in uterus, syndrome of yin deficiency of liver and kidney, syndrome of stagnation of liver qi and spleen deficiency and syndrome of deficiency of spleen qi and stomach qi.