摘要
目的:探究雌激素缺乏对大鼠根尖周炎病变区TLR4表达的影响。方法:30只大鼠随机分为两组:OVX组、SHAM组,暴露下颌第一磨牙髓腔,分别于开髓后0、7、14、21d处死大鼠。HE染色、酶组织化学染色、免疫组织化学法观测根尖周组织骨吸收范围,破骨细胞数及TLR4的表达。结果:与SHAM组相比,OVX组根尖周炎病变区骨吸收范围增大、破骨细胞数升高、TLR4的表达增强。结论:雌激素缺乏可增强大鼠根尖周炎病变区TLR4的表达。
Objective： To investigate the effects of estrogen deficiency on the expression of TLR4 in periapical le- sions of rats. Methods.. Thirty female rats were randomly divided into 2 groups： OVX group and SHAM group. The pulp cavities of mandibular first molars of rats were exposed. The rats were sacrificed at 0, 7, 14 and 21days after the exposure. Histologic examination for periapical bone loss area, enzyme histochemical examination for tar- trate--resistant acid phosphatase （TRAP）, and immunohistochemical examination for TLR4 were performed. Re- suits： The alveolar bone loss area, osteoclasts number, and the expression of TLR4 in OVX group were higher than those of SHAM group. Conclusion.. Estrogen deficiency increased the expression of TLR4 in the periapical＇lesions of rats.
出处
《口腔医学研究》
CAS
CSCD
北大核心
2015年第8期755-758,共4页
Journal of Oral Science Research
基金
国家自然科学基金重点项目(编号:30930099)国家自然科学基金国际(地区)合作与交流项目(编号:81120108010)
