期刊文献+

小分子RNA在干细胞成骨及成软骨分化中的作用 被引量:3

Effects of MicroRNA on the Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells
下载PDF
导出
摘要 小分子RNA(microRNA,miRNA)是内源性非编码单链小分子RNA,具有重要的生物学功能,对基因进行转录后调控,从而参与调节细胞增殖和分化,影响个体生长发育和疾病的发生过程。近年来越来越多的研究显示miRNA对间充质干细胞的成骨和成软骨向分化起着重要的调节作用,本文就miRNA在这方面的研究进展做一综述。 MicroRNA (miRNA) is endogenous, non-coding RNA with important biological function, and regu- lates cell proliferation and differentiation in the post-transcriptional processes, which affects the development of body and diseases. More and more recent researches have shown that miRNA regulated osteogenic and chondrogenic differentiation of mesenchymal stem cells, which is reviewed in this article.
出处 《口腔医学研究》 CAS CSCD 北大核心 2015年第8期845-847,共3页 Journal of Oral Science Research
基金 基金资助国家自然科学基金(青年科学基金项目:81100758/H1405) 天津市高等学校科研基金项目(编号:2010134)
关键词 小分子RNA 成骨 成软骨 分化 MicroRNA Osteogenic Chondrogenic Differentiation
  • 相关文献

参考文献21

  • 1Barrel DP. MicroRNAs: genomics, biogenesis, mechanism and function [J]. Cell, 2004, 116(2) : 281-297.
  • 2Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenehymal stem cell [J]. Sci- ence, 1999, 284(5411) : 143-147.
  • 3Yi R, Qin Y, Macara IG, et al. Exportin-5 mediates the nuclear export of pre-microRNA and short hairpin RNAs [J]. GenesDev, 2003, 17(24) : 3011-3016.
  • 4Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing [J]. Nature, 2007, 448 (7149):83-86.
  • 5Friedman RC, Farh KKH, Btlrge CB, et al. Most mammali- an mRNA are conserved targets of microRNAs [J]. Genome Res, 2009, 19(1) : 92-105.
  • 6Huang Y, Shen XJ, Zou Q, et al. Biological functions of mi- croRNAs: a review[J]. J Physicol Biochem, 2011, 67(1) : 129-139.
  • 7Oskowttz AZ, Lu J, Penfornts P, etal. Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression [J]. Proe Natl Acad Sci U S A, 2008, 105(47) : 18372- 18377.
  • 8Harfe BD, McManus MT, Mansfield JH, et al. The RNase m enzyme Dicer is required for morphogenesis but not pat-terning of the vertebrate limb [J].Proc Natl Acad Sci U S A, 2005, 102(31): 10898-10903.
  • 9Eskildsen T, Taipaleenmaki H, Stenvang J, etal. Micr0R- NA-138 regulates osteogenic differentiation of human stro- real (mesenchymal) stem cells in vivo [J]. Proe Natl Aead Sci U S A, 2011, 108(15) : 6139-6144.
  • 10Itoeh T, Ando M, Tsukamasa Y, et al. Expression of BMP -2 and Etsl in BMP- 2- stimulated mouse pre-osteoblast differentiation ls regulated by microRNA- 370[J]. FEBS Letters, 2012, 586(12) : 1693-1701.

同被引文献13

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部