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肝X受体：一个肿瘤预防、治疗潜在的生物靶点 被引量：1

Liver X receptors：a potential biological target for prevention and treatment of tumor
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摘要 肝x受体（1iverXreceptors，LXRs）作为配体依赖的核受体家族成员，参与机体胆固醇、脂肪、糖类代谢，以及调节机体的炎症活动。近来研究发现，LXRs同时具有抗肿瘤功效，结合不良反应小等特点，LXRs可作为肿瘤治疗的新型靶点，现对LXRs抗肿瘤机制及研究进展进行综述。 Liver X receptors （LXRs） belong to the ligand-dependent nuclear receptor family and participate in the modulation of cholesterol, fatty acid, glucose metabolism and inflammatory responses. Recent studies have found LXRs also have an antitumoral effect. Combining with the characteristics of less adverse reactions,LXRs can be considered as a novel antitumoral therapeutic target. This review aims to discuss the antitumoral mechanisms and the current strategies of LXRs.
作者 陈琼琚 史莹 谷伟
机构地区 南京医科大学附属南京医院呼吸内科
出处 《国际呼吸杂志》 2015年第16期1277-1280,共4页 International Journal of Respiration
关键词 肝X受体 肿瘤 Liver X receptors Tumor
分类号 R730.1 [医药卫生—肿瘤]
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参考文献40

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国际呼吸杂志
2015年 第16期

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