替古奥联合华赡索片在胃癌晚期老年患者疗效及安全性观察

观察胃癌晚期不可切除或复发患者(年龄≥70岁)使用替吉奥单药化疗联合华蟾素的疗效以及毒剐反应。方法:选取成都医学院第一附属医院2007~2013年确诊的晚期老年胃癌患者60例,年龄375岁。采用对照法进行分析,随机分为治疗组和对照组各30例,治疗组给予替吉奥胶囊联合华蟾素片,对照组给予5-Fu静脉滴注。结果:治疗组总有效率为33.3%,对照组总有效率为20%,差异无统计学意义(P=0.243);治疗组疾病控制率为73.3%,对照组疾病控创率为43.3%,差异有统计学意义(P=0.018),治疗组优于对照组。治疗组免疫状态较治疗组改善,治疗组毒副作用发生情况明显低于对照组,以减轻口腔黏膜、皮疹症状更为明显,差异均有统计学意义(P〈0.05)。结论:替吉奥联合华蟾素片对于老年晚期胃癌患者疗效确切,能改善患者免疫状态,并发症少,特则是能减轻患者黏膜及皮肤反应,患者耐受性好,但仍需大样本、高质量、长期随机对照试验的进一步验证。

Objective :To observe the gastric cancer patients with unresectable or recurrence ( age 70 or higher ) used for gonow single - agent chem- otherapy combined HuaChan curative effect and adverse reaction. Methods:the 60 elderly patients with metastatic or recurrent un - resectable gastric cancer were randomized to either control group or treatment group. 30 patients of treatment group were treated with S - 1 plus cinobufacin,30 patients of control group were treated with 5 - Fu alone. Results: In treatment group,Disease Control Rate was 73.3% ,and that of control group was 43.3% ,and can prove the immune state, the treatment group had less adverse reaction, specicl can improve Oral cavity mucosa effect and rash, had significance (P 〈 0. 05 ). Con- clusion: S1 combined with cinobufacln in treating the elderly patients is effective ,safe in treatment of metastatic or recurrent un- resectable gastric cancer, but the results suggest that further and larger -scale trials for the elderly patients with metastatic or recurrent un -resectable gastric cancer are needed.