凝血四项及D-二聚体的检测在肝硬化患者中的应用体会

Evaluation of Four Coagulation Tests and D-Dimer in Patients With Liver Cirrhosis

目的：凝血四项及 D-二聚体的检测在肝硬化患者中的应用体会。方法选取郑州卷烟厂康复医院2013年10月～2015年1月进行凝血四项和 D-二聚体检测的患者100例，其中被诊断为肝硬化的患者50例作为研究组，指标正常的体检患者50例作为对照组，对两组患者凝血四项及 D-二聚体各指标进行统计分析。结果肝硬化组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和凝血酶时间（TT）较对照组延长，纤维蛋白（FIB）浓度较对照组低，D-二聚体（D-Dimer）浓度较对照组高（P ＜0.05）。结论进行凝血四项及 D-二聚体的检测，对于评价肝硬化患者体内凝血状况、预估出血倾向，具有重要的临床价值。

Objective To evaluate the determination of four coagulation tests and D-Dimer in patients with liver cirrhosis. Methods Select 100 patients in Rehabilitation hospital of Zhengzhou cigarette factory with the 〈br〉 determination of the four coagulation tests and D-Dimer from October 2013 to January 2015, which 50 cases were diagnosed as liver cirrhosis as study group, indicators of normal physical examination in 50 cases as control group, the results of two groups with four coagulation tests and D-Dimer were statistical analyzed. Results Prothrombin time＆amp; activated partial thromboplastin time＆amp; thrombin time in study group were longer than control group. Concentrations of fibrinogen in study group were lower than control group. Concentrations of D-Dimer in study group were higher than control group.The difference between two groups has statistical significance （P〈0.05）. Conclusion For patients with liver cirrhosis, the determination of four coagulation tests and D-Dimer, it has value in evaluating the patients’ coagulation system and predictive value in identifying patients at risk for bleeding complications.